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Autophagy is emerging as one of the alternative cell death mechanisms and is well known to cross\u2010talk with apoptosis. Autophagy can act as a viable option to treat highly resistant PC. The current study investigates and provides insight into the autophagic and apoptotic cell death induced by quinoline derivative 2\u2010(6\u2010methoxynaphthalen\u20102\u2010yl)quinolin\u20104\u2010amine (6MN\u20104\u2010AQ) in PC cell lines PANC\u20101 and MIA PaCa\u20102. Treatment with 6MN\u20104\u2010AQ reduced cell viability in concentration dependent manner (2\u201316\u2009\u03bcM) and inhibited the clonogenic potential of PC cells at a concentration of 4\u00a0\u03bcM for 24\u2009h. Further, we found that 6MN\u20104\u2010AQ induced both apoptosis and autophagic cell death simultaneously. We identified that 6MN\u20104\u2010AQ induced autophagic cell death by forming cytoplasmic vacuoles, the elevation of autophagy flux, increase in LC3\u2010II, Beclin\u20101 protein expression, and degradation of p62. Moreover, 6MN\u20104\u2010AQ induced apoptosis via Caspase\u20103 activation and cleavage of PARP in PC cells. Upon investigating the underlying mechanism associated with 6MN\u20104\u2010AQ induced cell death, it was observed that 6MN\u20104\u2010AQ treatment is able to suppress the Akt\/mTOR pathway and induced ER stress leading to the induction of autophagy. Also, 6MN\u20104\u2010AQ treatment suppressed epithelial to mesenchymal transition by reducing the protein expression of SLUG, snail, and vimentin. Subsequently, 6MN\u20104\u2010AQ inhibited cell migration and invasion by down regulating MMP\u20107 and MMP\u20109 protein expression, suggesting that 6MN\u20104\u2010AQ may serve as a plausible therapeutic agent for PC.<\/jats:p>","DOI":"10.1002\/ddr.21916","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T04:21:15Z","timestamp":1643430075000},"page":"910-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Autophagic and apoptotic cell death induced by the quinoline derivative 2\u2010(6\u2010methoxynaphthalen\u20102\u2010yl)quinolin\u20104\u2010amine in pancreatic cancer cells is via <scp>ER<\/scp> stress and inhibition of Akt\/<scp>mTOR<\/scp> signaling pathway"],"prefix":"10.1002","volume":"83","author":[{"given":"Habeebunnisa","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Applied Biology CSIR\u2010Indian Institute of Chemical Technology  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