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Herein, we aimed to explore the potential role and mechanism of circRNA oligophrenin 1 (circ\u2010OPHN1; hsa_circ_0007445) in PE. Quantitative real\u2010time polymerase chain reaction (qPCR) and western blot were utilized to detect gene expression levels. The biological behaviors of trophoblast cells were determined by 3\u2010(4,5\u2010dimethyl\u20102\u2010thiazolyl)\u22122,5\u2010diphenyl\u20102\u2010H\u2010tetrazolium bromide (MTT), flow cytometry, transwell, and wound healing methods. The binding relationship between microRNA\u2010558 (miR\u2010558) and circ\u2010OPHN1 or thrombospondin 2 (THBS2) was validated via dual\u2010luciferase reporter assay. Circ\u2010OPHN1 and THBS2 levels were enhanced, while miR\u2010558 level was declined in PE placental tissues. Circ\u2010OPHN1 or THBS2 overexpression hindered the proliferation, migration, and invasion of trophoblast cells. In addition, circ\u2010OPHN1 sequestered miR\u2010558 to regulate THBS2 expression, thereby repressing the growth and mobility of trophoblast cells. Circ\u2010OPHN1 inhibited trophoblast cell proliferation, migration, and invasion through mediating miR\u2010558\/THBS2 axis, providing a novel pathway for PE pathogenesis.<\/jats:p>","DOI":"10.1002\/ddr.21931","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T23:29:35Z","timestamp":1647041375000},"page":"1034-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Circ\u2010OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR\u2010558\/THBS2 axis"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5974-2402","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Affiliated Hospital of Putian University  Putian City Fujian Province 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