{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:47:02Z","timestamp":1780357622425,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With increased life expectancies in developed countries, cancer rates are becoming more common among the elderly. Cancer is typically driven by a combination of germline and somatic mutations accumulating during an individual's lifetime. Yet, many centenarians reach exceptionally old age without experiencing cancer. It was suggested that centenarians have more robust DNA repair and mitochondrial function, allowing improved maintenance of DNA stability. In this study, we applied real\u2010time quantitative PCR to examine the expression of <jats:italic>ATM<\/jats:italic> in lymphoblastoid cell lines (LCLs) from 15 healthy female centenarians and 24 younger female donors aged 21\u201388 years. We observed higher <jats:italic>ATM<\/jats:italic> mRNA expression of in LCLs from female centenarians compared with both women aged 21\u201348 years (FD\u2009=\u20092.0, <jats:italic>p<\/jats:italic>\u2009=\u2009.0016) and women aged 56\u201388 years (FD\u2009=\u20091.8, <jats:italic>p<\/jats:italic>\u2009=\u2009.0094. Positive correlation was found between <jats:italic>ATM<\/jats:italic> mRNA expression and donors age (<jats:italic>p<\/jats:italic>\u2009=\u2009.0028). Levels of hsa\u2010miR\u2010181a\u20105p, which targets <jats:italic>ATM<\/jats:italic>, were lower in LCLs from centenarians compared with younger women. Our findings suggest a role for ATM in protection from age\u2010related diseases, possibly reflecting more effective DNA repair, thereby reducing somatic mutation accumulation during aging. Further studies are required for analyzing additional DNA repair pathways in biosamples from centenarians and younger age men and women.<\/jats:p>","DOI":"10.1002\/ddr.21972","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T02:04:57Z","timestamp":1656641097000},"page":"1419-1424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Higher <i>ATM<\/i> expression in lymphoblastoid cell lines from centenarian compared with younger women"],"prefix":"10.1002","volume":"83","author":[{"given":"Adva","family":"Hadar","sequence":"first","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Molecular Genetics Weizmann Institute of Science  Rehovot 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Centre of Postgraduate Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-0657","authenticated-orcid":false,"given":"Jacek","family":"Ku\u017anicki","sequence":"additional","affiliation":[{"name":"The International Institute of Molecular and Cell Biology in\u00a0Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2430","authenticated-orcid":false,"given":"Illana","family":"Gozes","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv\u00a0University  Tel Aviv 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