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Diosgenin has a wide range of pharmacological activities, and has been used to treat cancer, nervous system diseases, inflammation, and infections. Numerous studies have shown that diosgenin has potential therapeutic value for lipid metabolism diseases via various pathways and mechanisms, such as controlling lipid synthesis, absorption, and inhibition of oxidative stress. These mechanisms and pathways have provided ideas for researchers to develop related drugs. In this review, we focus on data from animal and clinical studies, summarizing the toxicity of diosgenin, its pharmacological mechanism, recent research advances, and the related mechanisms of diosgenin as a drug for the treatment of lipid metabolism, especially in obesity, hyperlipidemia, nonalcoholic fatty liver disease, atherosclerosis, and diabetes. This systematic review will briefly describe the advantages of diosgenin as a potential therapeutic drug and seek to enhance our understanding of the pharmacological mechanism, recipe\u2010construction, and the development of novel therapeutics against lipid metabolism diseases.<\/jats:p>","DOI":"10.1002\/ddr.21991","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T14:59:27Z","timestamp":1663685967000},"page":"1725-1738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic potential and research progress of diosgenin for lipid metabolism diseases"],"prefix":"10.1002","volume":"83","author":[{"given":"Shi\u2010Zhao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan Shandong 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