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It interferes with daily functioning and affects the quality of life of the patient. There is a clear need to investigate nonopioid or non\u2010nonsteroidal anti\u2010inflammatory drug alternatives for the treatment of pain. In this study, we determined the effect of acute pre\u2010 and posttreatment with pramipexole (PPX), a dopamine D2\/D3 selective agonist, on formalin 1%\u2010induced acute and long\u2010lasting nociceptive behavior sensitivity in rats. Moreover, we sought to investigate whether the antiallodynic and antihyperalgesic effect induced by PPX was mediated through the nuclear factor\u2010\u03baB\u00a0(NF\u2010kB) signaling pathway. Moreover, acute systemic pretreatment with PPX (1 and 3\u2009mg\/kg, ip) suppressed the formalin\u2010induced nociceptive behavior during both phases of the formalin test and the development of formalin\u2010induced secondary mechanical allodynia and hyperalgesia in both paws. Acute systemic posttreatment with PPX (3\u2009mg\/kg, ip) reverted the formalin\u2010induced long\u2010lasting secondary mechanical allodynia and hyperalgesia. Furthermore, PPX inhibits the protein expression of NF\u2010\u03baB\u2013p65 and the levels of tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 in the spinal cord of animals with secondary mechanical allodynia and hyperalgesia induced by formalin. These data suggest that PPX has a potential role in producing anti\u2010inflammatory activity. Moreover, the antiallodynic and antihyperalgesic effects induced by PPX can be mediated through the NF\u2010kB signaling pathway.<\/jats:p>","DOI":"10.1002\/ddr.22029","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T08:00:07Z","timestamp":1674028807000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pramipexole inhibits formalin\u2010induce acute and long\u2010lasting mechanical hypersensitivity via NF\u2010kB pathway in rats"],"prefix":"10.1002","volume":"84","author":[{"given":"Jazm\u00edn","family":"Santamaria\u2010Anzures","sequence":"first","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud Universidad Aut\u00f3noma Metropolitana\u2010Xochimilco Mexico City 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