{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:22:33Z","timestamp":1787066553710,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Copper ions play a crucial role in the progression of cancers. Tumor tissue is rich in copper ions, and copper chelators could potentially scavenge these copper ions and thus exert an antitumor effect. In this study, we report the synthesis of a novel thieno[3,2\u2010\n                    <jats:italic>c<\/jats:italic>\n                    ]pyridine compound we have called \u201c\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    \u201d that can act as the copper chelator thanks to the inclusion of an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(pyridin\u20102\u2010yl)acetamide moiety that targets copper ions.\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    potently inhibited cancer proliferation, inducing cell apoptosis and impairing the extracellular acidification rate\u00a0and oxygen consumption rate of colorectal cancer (CRC) cells.\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    also inhibited the growth of a CRC\u2010transplanted tumor in a dose\u2010dependent manner, inducing apoptosis of the tumor cells and promoting the infiltration of lymphocytes in the CRC\u2010transplanted\u00a0tumor tissues.\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    also enhanced the antitumor effects of the programmed cell death protein 1 (PD\u20101) inhibitor. The relatively benign nature of\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    was demonstrated by the effect on normal cell viability and acute toxicity tests in mice. Our findings suggest that\n                    <jats:bold>JYFY\u2010001<\/jats:bold>\n                    is a prospective copper chelator to be used as a targeted drug and a synergist of immunotherapy for CRC treatments.\n                  <\/jats:p>","DOI":"10.1002\/ddr.22034","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:25:50Z","timestamp":1674174350000},"page":"312-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A novel copper chelator for the suppression of colorectal cancer"],"prefix":"10.1002","volume":"84","author":[{"given":"Xiaolong","family":"Shi","sequence":"first","affiliation":[{"name":"Medical Research Center Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine  Jinan Shandong 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