{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:16:21Z","timestamp":1787325381771,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pathological cardiac hypertrophy is the result of a prolonged increase in the workload of the heart that activates various signaling pathways such as MAPK pathway, PKA\u2010dependent cAMP signaling, and CaN\u2010NFAT signaling pathway which further activates genes for cardiac remodeling. Various signalosomes are present in the heart that regulates the signaling of physiological and pathological cardiac hypertrophy. mAKAP\u03b2 is one such scaffold protein that regulates signaling pathways involved in promoting cardiac hypertrophy. It is present in the outer nuclear envelope of the cardiomyocytes, which provides specificity of the target toward\u00a0the heart. In addition, nuclear translocation of signaling components and transcription factors such as MEF2D, NFATc, and HIF\u20101\u03b1 is facilitated due to the localization of mAKAP\u03b2 near the nuclear envelope. These factors are required for activation of genes promoting cardiac remodeling. Downregulation of mAKAP\u03b2 improves cardiac function and attenuates cardiac hypertrophy which in turn prevents the development of heart failure. Unlike earlier therapies for heart failure, knockout or silencing of mAKAP\u03b2 is not associated with side effects because of its high specificity in the striated myocytes. Downregulating expression of mAKAP\u03b2 is a favorable therapeutic approach toward\u00a0attenuating cardiac hypertrophy and hence preventing heart failure. This review discusses mAKAP\u03b2 signalosome as a potential target for cardiac hypertrophy intervention.<\/jats:p>","DOI":"10.1002\/ddr.22081","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T01:33:46Z","timestamp":1684460026000},"page":"1072-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["mAKAP\u03b2 signalosome: A potential target for cardiac hypertrophy"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-1671","authenticated-orcid":false,"given":"Vaishnavi","family":"Golatkar","sequence":"first","affiliation":[{"name":"Department of Pharmacology SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-9300","authenticated-orcid":false,"given":"Lokesh K.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540701358593"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.153007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.01.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072647999"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040846"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.10.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.19.8467-8476.2004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2014.BAB146"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16-572"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.8.1921"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109357"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.03.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2006.01.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03966"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092164"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-04-0878"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.098699"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10040346"},{"key":"e_1_2_10_21_1","first-page":"14","article-title":"Calcineurin\u2010AKAP interactions: Therapeutic targeting of a pleiotropic enzyme with a little help from its friends","volume":"598","author":"Gildart M.","year":"2020","journal-title":"The Journal of Physiology C"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00105"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61084"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117914"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.08.084"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000062465.60601.CC"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33255"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209320"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.05.005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001266"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd5010009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0255-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.276162"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.10.023"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044805"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.12.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1343"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.785"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","unstructured":"Martinez E. C. Li J. Ataam J. A. Tokarski K. Thakur H. Karakikes I. Dodge\u2010Kafka K. &Kapiloff M. S.(2022).Targeting MAKAP\u03b2 expression as a therapeutic approach for ischemic cardiomyopathy.Gene Therapy.","DOI":"10.1038\/s41434-022-00321-w"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1383"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00041.2008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.164947"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.1.61"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000194325.31359.86"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2007.11.012"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-2-2"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.11.2757"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02675"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.10.009"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00237.2013"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000206"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2009"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221999110"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.900437"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.06.001"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.168138"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.04.022"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1477-x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.01.014"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.03.017"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.282442"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.040403.114521"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.21.7603-7613.2002"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2020"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000026"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049268"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.04.006"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00719.2010"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211566798"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22441"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.22081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:18:24Z","timestamp":1760390304000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.22081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ddr.22081"],"URL":"https:\/\/doi.org\/10.1002\/ddr.22081","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"assertion":[{"value":"2022-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}