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In this study, we have elucidated the mechanism of action of lead compounds, wherein they target the cell wall of <jats:italic>S. aureus<\/jats:italic>. Further, <jats:italic>S. aureus<\/jats:italic> failed to develop resistance against two lead compounds tested in a serial passage experiment in the presence of the compounds over a period of 40 days. Both the compounds demonstrated comparable in vivo efficacy with vancomycin in a neutropenic mice thigh infection model. The results of these antibacterial activities emphasize the excellent potential of thioethers for developing novel antibiotics and may fill in as a target for the adjustment of accessible molecules to develop new powerful antibacterial agents with fewer side effects.<\/jats:p>","DOI":"10.1002\/ddr.22123","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:26:59Z","timestamp":1697423219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Indole\u2010based aryl sulfides target the cell wall of <i>Staphylococcus aureus<\/i> without detectable resistance"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-4749","authenticated-orcid":false,"given":"Aditya G.","family":"Lavekar","sequence":"first","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-2519","authenticated-orcid":false,"given":"Ritesh","family":"Thakare","sequence":"additional","affiliation":[{"name":"Division of Molecular Microbiology and Immunology CSIR\u2010Central Drug Research Institute Lucknow Uttar Pradesh India"},{"name":"Department of Cell and Cancer Biology UMass Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-636X","authenticated-orcid":false,"family":"Saima","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"School of Advanced Chemical Sciences  Solan Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-4714","authenticated-orcid":false,"given":"Danish","family":"Equbal","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-6074","authenticated-orcid":false,"given":"Sidharth","family":"Chopra","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  New Delhi India"},{"name":"Division of Molecular Microbiology and Immunology CSIR\u2010Central Drug Research Institute Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-9495","authenticated-orcid":false,"given":"Arun K.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  New Delhi India"},{"name":"Ranchi University  Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1706.101037"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq251"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.119"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1914-1920.2002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.10.011"},{"key":"e_1_2_11_9_1","unstructured":"Centers for Disease Control and Prevention (CDC). 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