{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:41:02Z","timestamp":1788381662815,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The three\u2010components one\u2010pot Kabachnik\u2010Fields reaction of sulfapyridine, diethyl phosphite, and aldehyde under thermal catalysis reaction condition in the presence of bismuth (III) triflate as a catalyst afford the corresponding sulfonamide\u2010phosphonates (<jats:bold>3a\u22123p<\/jats:bold>) in good to excellent yields (78%\u221291%). The structures of the new synthesized compounds were elucidated and confirmed by variable spectroscopic studies. Single crystal X\u2010ray studies for <jats:bold>3a<\/jats:bold>, <jats:bold>3d<\/jats:bold>, and <jats:bold>3i<\/jats:bold> verified the proposed structure. The newly developed sulfonamide\u2010phosphonates were evaluated for their inhibitory properties against four isoforms of human carbonic anhydrase (hCA I, II, IX, and XII). The results demonstrated that they exhibited greater potency in inhibiting hCA XII compared to hCA I, II, and IX, with K<jats:sub>i<\/jats:sub> ranging from 5.1 to 51.1\u2009nM. Compounds <jats:bold>3l<\/jats:bold> and <jats:bold>3p<\/jats:bold> displayed the highest potency, exhibiting selectivity ratios of I\/XII &gt;298.7 and 8.5, and II\/XII ratios of 678.1 and 142.1, respectively. Molecular docking studies were conducted to explore their binding patterns within the binding pocket of CA XII. The results revealed that the sulfonamide NH group coordinated with the Zn<jats:sup>2+<\/jats:sup> ion, and hydrogen bond interactions were observed with residue Thr200. Additionally, hydrophobic interactions were identified between the benzenesulfonamide phenyl ring and Leu198. Compounds <jats:bold>3p<\/jats:bold> and <jats:bold>3l<\/jats:bold> exhibited an additional hydrogen bonding interaction with other amino acid residues. These supplementary interactions may contribute to the enhanced potency and selectivity of these compounds toward the CA XII isoform.<\/jats:p>","DOI":"10.1002\/ddr.22135","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T19:53:08Z","timestamp":1700855588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel sulfonamide\u2010phosphonate conjugates as carbonic anhydrase isozymes inhibitors"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-0798","authenticated-orcid":false,"given":"Mohamed S.","family":"Bekheit","sequence":"first","affiliation":[{"name":"Department of Pesticide Chemistry National Research Centre Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Sabry","sequence":"additional","affiliation":[{"name":"Department of Pesticide Chemistry National Research Centre Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Applied Organic Chemistry Department National Research Centre Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewies F.","family":"Ewies","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department National Research Centre Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson M.","family":"Kariuki","sequence":"additional","affiliation":[{"name":"School of Chemistry Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-8683","authenticated-orcid":false,"given":"Marwa A.","family":"Fouad","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Cairo University Cairo Egypt"},{"name":"Pharmaceutical Chemistry Department, School of Pharmacy New Giza University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Chemistry University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Chemistry University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.617745"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030316"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272821666170113114456"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.698264"},{"key":"e_1_2_7_8_1","unstructured":"DrugBank. 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