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Ph<jats:sub>3<\/jats:sub>M(L)<jats:sub>2<\/jats:sub> type complexes were synthesized, where M\u2009=\u2009Sb(V) or Bi(V) and L\u2009=\u2009deprotonated 3\u2010(dimethylamino)benzoic acid or 2\u2010acetylbenzoic acid. Both organobismuth(V) and organoantimony(V) complexes exhibited efficacy at micromolar concentrations against <jats:italic>Leishmania amazonensis<\/jats:italic> and <jats:italic>L. infantum<\/jats:italic> but only the later ones demonstrated biocompatibility. Ph<jats:sub>3<\/jats:sub>Sb(L1)<jats:sub>2<\/jats:sub> and Ph<jats:sub>3<\/jats:sub>Bi(L1)<jats:sub>2<\/jats:sub> demonstrated distinct susceptibility profiles compared to inorganic Sb(III)\u2010resistant strains of MRPA\u2010overexpressing <jats:italic>L. amazonensis<\/jats:italic> and AQP1\u2010mutated <jats:italic>L. guyanensis<\/jats:italic>. These complexes were able to permeate the cell membrane and interact with the <jats:italic>Leishmania<\/jats:italic> DNA, suggesting that this effect may contribute to the parasite growth inhibition via apoptosis. Taken altogether, our data substantiate the notion of a distinct mechanism of uptake pathway and action in <jats:italic>Leishmania<\/jats:italic> for these organometallic complexes, distinguishing them from the conventional inorganic antimonial drugs.<\/jats:p>","DOI":"10.1002\/ddr.22194","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T12:09:30Z","timestamp":1714910970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Susceptibility of <i>Leishmania<\/i> to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)\u2010sensitive and \u2010resistant strains"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-4816","authenticated-orcid":false,"given":"Arshad","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Postgraduate Program in Physiology and Pharmacology, Institute of Biological Sciences Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Chemistry, Institute of Exact Sciences Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pathology Government Lady Reading Hospital Medical Teaching Institution  Peshawar Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Rodrigues","family":"do Prado","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Exact Sciences Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalton","family":"Dittz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Health Sciences Center Federal University of Piau\u00ed (UFPI), Av. 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