{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:13:13Z","timestamp":1789999993220,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inhibition of SIRT3 triggered differentiation of multiple myeloma (MM) cells. In discovery of potent SIRT3 inhibitors for cancer differentiation therapy, structural modification was performed on the previously developed lead compound\n                    <jats:bold>S27<\/jats:bold>\n                    . A total of 49 compounds divided into two series were designed and synthesized. In the enzyme inhibitory assay, several molecules (\n                    <jats:bold>A7<\/jats:bold>\n                    ,\n                    <jats:bold>A13<\/jats:bold>\n                    ,\n                    <jats:bold>B15<\/jats:bold>\n                    , and\n                    <jats:bold>B26<\/jats:bold>\n                    ) exhibited potent SIRT3 inhibitory activity and selectivity. Significantly, representative compounds, especially\n                    <jats:bold>A7<\/jats:bold>\n                    , promoted differentiation of MM cells from cancer phenotype to normal cells, accompanied by increased expression of antigen CD49e, human immunoglobulin light chain \u03bb\u2010IgLG and \u03ba\u2010IgLG. Additionally, molecule\n                    <jats:bold>A7<\/jats:bold>\n                    reversed growth factor IL\u20106 induced MM cell proliferation, improved the antiproliferative activity of Ixazomib and increased the apoptotic rate of MM cells treated with Ixazomib. Collectively, potent SIRT3 inhibitors with MM cell differentiation potency were developed for the cancer therapy used alone or in combination.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70016","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T14:10:17Z","timestamp":1731334217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovery of Novel SIRT3 Inhibitors for the Cancer Differentiation Therapy by Structural Modification"],"prefix":"10.1002","volume":"85","author":[{"given":"Honggang","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Du","sequence":"additional","affiliation":[{"name":"Taizhou Polytechnic College Taizhou Jiangsu 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