{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:08:17Z","timestamp":1790712497508,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mortalities due to mycoses have dramatically increased with the emergence of drug\u2010resistant strains and growing immune\u2010compromised populations globally. Azole antifungals have been the first choice against fungal infections of a wide spectrum and several azole derivatives with ester function were reported for their potentially promising and favorable activity against\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. In this study, we designed and synthesized a series of 1\u2010(aryl)\u22122\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    \u2010imidazol\u20101\u2010yl\/1\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,4\u2010triazol\u20101\u2010yl)ethyl esters, and tested them against seven reference\n                    <jats:italic>Candida<\/jats:italic>\n                    strains using EUCAST reference microdilution method. Among the series,\n                    <jats:bold>6a<\/jats:bold>\n                    ,\n                    <jats:bold>6d<\/jats:bold>\n                    , and\n                    <jats:bold>6g<\/jats:bold>\n                    proved highly potent in vitro compared to fluconazole; especially against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    with minimum inhibitor concentration (MIC) values as low as 0.125 and 0.06\u2009mg\/L, respectively, although their activities against\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    and\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    remained limited. The compounds also showed minimal toxicity to murine fibroblasts according to the in vitro cytotoxicity tests. Molecular modeling predicted\n                    <jats:bold>6g<\/jats:bold>\n                    as an orally available druglike compound according to all parameters and CYP51 inhibition as the likely mechanism for their antifungal effects. The study underpins the promise of azoles with ester functionality as a potential scaffold for small\u2010molecule antifungal drug design.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70021","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T23:50:16Z","timestamp":1731887416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Ester\u2010Containing Azole Derivatives With Potent Anti\u2010\n                    <i>Candida<\/i>\n                    Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies"],"prefix":"10.1002","volume":"85","author":[{"given":"Yusuf","family":"Ataker","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ba\u015fkent University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"\u00d6nc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-0439","authenticated-orcid":false,"given":"Dolunay","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Sabuncuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevtap","family":"Arikan\u2010Akdagli","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-4218","authenticated-orcid":false,"given":"Suat","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"1","article-title":"EUCAST DEFINITIVE DOCUMENT E.DEF 7.3.2: Method for the Determination of Broth Dilution Minimum Inhibitory Concentrations of Antifungal Agentsfor Yeasts","volume":"7","author":"Arendrup M. 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