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The chemical composition of the generated products has been investigated via mass spectroscopy, <jats:sup>1<\/jats:sup>HNMR, <jats:sup>13<\/jats:sup>CNMR, infrared, and elemental analyzes. Antimicrobial studies were conducted in vitro to evaluate the activity of all new synthesized compounds against resistant strains. The first series showed high potency in very low concentrations. All compounds were studied against DPPH Radical Scavenging Activity and the other series showed high activity even in low molar ratio. In silico molecular docking was used to investigate the potential binding pathways for different receptors: dihydroprotien synthase protein (ID Code: 1AJ0) as an antibacterial and EGFR<jats:sup>WT<\/jats:sup> co\u2010crystallized with erlotinib [PDB ID code 1m17]. Furthermore, synthesized compounds with good ADME predictions to the Lipinski rule of five demonstrated that the recently synthesized compounds had high drug\u2010likeness qualities when the physicochemical parameter for the most powerful novel candidates was determined. Moreover, the DFT\/B3LYP method functionalized with a 6\u201031G (d, p) basis set was employed to calculate quantum parameters, MEP analysis, HUMO, and LUMO.<\/jats:p>","DOI":"10.1002\/ddr.70029","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:03:32Z","timestamp":1734321812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fluorinated Sulfonamides: Synthesis, Characterization, <i>In Silico<\/i>, Molecular Docking, ADME, DFT Predictions, and Structure\u2010Activity Relationships, as Well as Assessments of Antimicrobial and Antioxidant Activities"],"prefix":"10.1002","volume":"85","author":[{"given":"Mohamed A. M. 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