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Symptoms include double vision, muscle weakness, and difficulty with coordination. Genetic and viral infections have been proposed as plausible factors responsible for MS. Although there is no cure for MS, treatment prevents future attacks. At present, chemotherapy and monoclonal antibodies are the available treatments for MS. Heterocyclic compounds are currently being tested clinically for their efficacy. Some heterocyclic scaffolds have been found to be promising for the treatment of MS. In view of this, research has been conducted towards the design and discovery of chemical agents for MS. Hence, the literature relevant to drug design for MS in the last decade has been collated and described comprehensively so that it would be helpful for efficient drug design for MS in the future. Additionally, through the structure\u2013activity relationship, the importance of crucial structural features was emphasized. The classification was primarily based on the type of heterocycle.<\/jats:p>","DOI":"10.1002\/ddr.70059","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T05:57:42Z","timestamp":1738735062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Experimentation of Heterocycles (2013\u201022) as Potent Pharmacophores in Drug Design of <i>Multiple Sclerosis<\/i>"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-8203","authenticated-orcid":false,"given":"Atukuri","family":"Dorababu","sequence":"first","affiliation":[{"name":"SKNG Government First Grade College Gangavathi 583227 Karnataka 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