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The inhibitory potentials of the derivatives against diabetes\u2010related enzymes such as aldose reductase (AR), \u03b1\u2010glycosidase (\u03b1\u2010GLY), and \u03b1\u2010amylase (\u03b1\u2010AMY) were experimentally determined, and the results were supported by molecular docking. The results showed that the derivatives (<jats:bold>3a<\/jats:bold>\u2013<jats:bold>3j<\/jats:bold>) displayed varied degree of potential inhibitory activity, with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values covering the following ranges: 5.47\u2009\u00b1\u20090.53 to 23.89\u2009\u00b1\u20091.46\u2009nM for AR and 1.76\u2009\u00b1\u20090.01 to 24.81\u2009\u00b1\u20090.15\u2009\u03bcM for \u03b1\u2010GLY, and with IC<jats:sub>50<\/jats:sub> values 4.94\u201328.17\u2009\u03bcM for \u03b1\u2010AMY, as compared to standard epalrestat and acarbose (<jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub>: 34.53\u2009\u00b1\u20092.52\u2009nM for AR and 23.53\u2009\u00b1\u20092.72\u2009\u03bcM for \u03b1\u2010GLY, respectively). The selective activity of these derivatives on antidiabetic enzymes may be important for the treatment of diabetes and may lead to the development of alternative new compounds for this purpose.<\/jats:p>","DOI":"10.1002\/ddr.70060","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T06:24:34Z","timestamp":1738736674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-9485","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Zonguldak Bulent Ecevit University Zonguldak 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