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The hypothesis that cholesterol\u2010PEG co\u2010modified poly (N\u2010butyl) cyanoacrylate nanoparticles (CLS\u2010PEG NPs) are an effective carrier for the treatment of brain tumors was verified, and the mechanism of its treatment for brain tumors was preliminarily explored. In this study, we used multifunctional poly (N\u2010butyl) cyanoacrylate nanoparticles modified with cholesterol and polyethylene glycol (PEG) as a drug delivery system to encapsulate the anticancer drug docetaxel (DTX). Cell anti\u2010proliferation tests showed that CLS\u2010PEG NPs increased the inhibitory effect of DTX. A pharmacokinetic study indicated that CLS\u2010PEG NPs achieved sustained release for 8\u2009h. These experimental results demonstrated that CLS\u2010PEG NPs amplified the concentration of the drug transported to the brain and sustained drug release in the brain. In addition, CLS\u2010PEG NPs led to better pharmacological efficacy in an orthotopic brain glioma rat model. The survival rate of rats in the CLS\u2010PEG NPs group was significantly prolonged to 28\u2009d. We also found that CLS\u2010PEG NPs inhibited M2 microglial polarization. These results indicate that CLS\u2010PEG NPs are a prospective drug delivery system for targeting brain tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ddr.70069","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:06:40Z","timestamp":1741691200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifunctional Docetaxel Cholesterol\u2010Polyethylene Glycol Co\u2010Modified Poly (N\u2010Butyl) Cyanoacrylate Nanoparticles for Brain Tumor Therapy"],"prefix":"10.1002","volume":"86","author":[{"given":"Xiao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nerve System Drugs Beijing Municipal Geriatric Medical Research Center Beijing 100053 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