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We describe the aspartate protease inhibition potentials of 12 sulfonyl\u2010containing imidazolidines (<jats:bold>5a\u2010l<\/jats:bold>) anti\u2010candidal agents. <jats:italic>Candida Albicans<\/jats:italic> secretes aspartic proteases (Saps), one of its most important virulent agents. These hydrolytic enzymes are critical for both fungal physiological processes and host\u2010fungus interactions. Compounds <jats:bold>5a\u2010l<\/jats:bold> were examined for their fungal aspartate protease inhibition apart from their anti\u2010candida activity. These findings were equipped and validated in silico using molecular docking and in vitro enzyme inhibition assays. The study found that imidazolidine derivatives inhibited aspartic protease and exhibited anti\u2010candida action. Conclusively, imidazolidines <jats:bold>5g, 5h,<\/jats:bold> and <jats:bold>5j<\/jats:bold> were perceived as the most potent anti\u2010candida compounds and are presently being evaluated for their preclinical studies.<\/jats:p>","DOI":"10.1002\/ddr.70074","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:11:15Z","timestamp":1743480675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imidazolidine\u2010Based Aspartate Inhibitors for Candida Infections"],"prefix":"10.1002","volume":"86","author":[{"given":"B.","family":"Bindu","sequence":"first","affiliation":[{"name":"Department of Chemistry Government Arts College Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7065-5884","authenticated-orcid":false,"given":"A.","family":"Manikandan","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha Medical College and Hospital Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jeevitha","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha Medical College and Hospital Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe Jacob","family":"Kunju","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha Medical College and Hospital Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vijayalakshmi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government Arts College Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2004.134"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.01.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-020-00658-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjmms.sjmms_625_21"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103171"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111912"},{"key":"e_1_2_8_8_1","unstructured":"Biovia D. 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