{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:50Z","timestamp":1792067750542,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dihydroartemisinin (DHA) is a derivative of artemisinin, which affects inflammation, oxidative stress, and immune regulation. However, the mechanism underlying its effects remains largely unknown. This study aims to explore the mechanism by which DHA affects radiation\u2010induced lung injury (RILI), providing new insights for lung radiotherapy. To elucidate its mechanism of action, C57BL\/6\u2009J mice were irradiated with 15\u2009Gy whole chest. RILI was evaluated by qRT\u2010PCR, ELISA, histology, Western blot analysis, immunohistochemistry, and RILI signaling cascade studies. In addition, small interfering RNAs were employed to knockdown cGAS proteins in the cGAS\u2010STING signaling pathway in the human bronchial epithelium cell line (BEAS\u20102B). Both In Vivo and Vitro experiments were conducted to investigate the specific mechanism by which DHA alleviated RILI. We observed the activation of the cGAS\u2010STING pathway, along with the phosphorylation of the downstream target NF\u2010\u03baB and an increase in inflammatory factor levels in the mouse model following radiation exposure. In the cell model, irradiation also triggered the activation of the cGAS\u2010STING signaling pathway and its downstream targets, leading to elevated levels of inflammatory factors. Notably, knocking down the cGAS using small interfering RNA in the BEAS\u20102B cells significantly alleviated RILI in the cell model. Our study elucidated the mechanism of DHA reducing RILI through the cGAS\/STING\/NF\u2010\u03baB signaling pathway, and revealed that the GAS\/STING\/NF\u2010\u03baB axis may be a potential therapeutic target for RILI.<\/jats:p>","DOI":"10.1002\/ddr.70090","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:46:18Z","timestamp":1745642778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dihydroartemisinin Attenuates Radiation\u2010Induced Lung Injury by Inhibiting the cGAS\/STING\/NF\u2010\u03baB Signaling Pathway"],"prefix":"10.1002","volume":"86","author":[{"given":"Cailan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of 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