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Our previous work produced a group of vinyl sulfones that function as irreversible covalent inactivators of this enzyme. We have now expanded this initial set to produce vinyl sulfones with higher kinetic efficiency as covalent inactivators of ASADH purified from the pathogenic fungal species\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . The catalytic efficiency of these inactivators has also been compared to related classes of irreversible inactivators, vinyl sulfonamides, acrylamides, and sulfonyl ketones.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70095","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:05:27Z","timestamp":1746687927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase"],"prefix":"10.1002","volume":"86","author":[{"given":"Samantha N.","family":"Friday","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Toledo Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liezel A.","family":"Koellner","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of North Carolina 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