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This study aimed to investigate the protective effects of caffeic acid against acrylamide\u2010induced reproductive dysfunction in male rats. Group 1 served as the control; group 2 received acrylamide at a dose of 40\u2009mg\/kg for 10 days. In groups, 3\u20136, acrylamide was given as in group 2, followed by therapy of caffeic acid (10, 20, 30, 40\u2009mg\/kg) for 3 consecutive days. It was found that acrylamide causes significant alteration in serum concentrations of FSH, testosterone, and LH; decreased sperm motility and viability. Acrylamide administration causes alteration in biochemical parameters including lipid peroxidation, reduced glutathione, and antioxidant enzymes (SOD and CAT) along with triglyceride, cholesterol, and seminal fructose. Moreover, acrylamide causes histological alterations and promotes DNA damage as evident by COMET assay. After caffeic acid treatment, serological, biochemical, and histological alterations returned to almost normal ranges. Based on our findings, it is reasonable to conclude that caffeic acid, a natural antioxidant, is a potential medication to lessen any harmful damage in male gonads brought on by acrylamide consumption.<\/jats:p>","DOI":"10.1002\/ddr.70103","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:10:49Z","timestamp":1747883449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose\u2010Dependent Improvement of Caffeic Acid Against Acrylamide\u2010Induced Male Reproductive Dysfunction"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-4561","authenticated-orcid":false,"given":"Divya","family":"Gupta","sequence":"first","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-389X","authenticated-orcid":false,"given":"Sadhana","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5814-8337","authenticated-orcid":false,"given":"Sangeeta","family":"Shukla","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Lab, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11356-021-14532-Y\/FIGURES\/9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-016874-6.50044-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12541"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFF.2023.105862"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12839"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20150402062823"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.18502\/IJRM.V21I1.12668"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/AND.14491"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5653\/CERM.2019.03230"},{"key":"e_1_2_10_11_1","volume-title":"Laboratory Manual for the Examination of Human Semen and Semen\u2010cervical Mucus Interaction: Based on Consultations Held Within","author":"Belsey M. 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