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As launch costs have decreased and commercial innovation has advanced, utilization of space for research has surged, with both space stations and nano\/microsatellites (CubeSats) serving as essential platforms for ground breaking experiments. This systematic review summarizing findings from 86 peer\u2010reviewed articles and major space research initiatives, focusing on the biological and medical insights gained from space\u2010based investigations. Studies conducted in microgravity have revealed significant alterations in bacterial physiology, including increased virulence and antibiotic resistance, as well as enhanced secondary metabolite production with potential pharmaceutical applications. Human physiological changes, such as muscle atrophy, bone demineralization, and cardiovascular deconditioning, mirror accelerated aging and disease states, providing valuable models for understanding and developing treatments for similar conditions on Earth. Space research has also highlighted the risk of kidney stone formation due to altered calcium metabolism and gut microbiome shifts, along with ophthalmological abnormalities such as Spaceflight\u2010Associated Neuro\u2010Ocular Syndrome (SANS), which offer insights into terrestrial eye diseases. Advanced technologies, including 3D bioprinting, lab\u2010on\u2010a\u2010chip, and tissue chips, have enabled sophisticated experiments in regenerative medicine and disease modeling. Microgravity facilitates the growth of high\u2010quality drug crystals, improving drug stability, efficacy, and delivery methods, as exemplified by innovations in monoclonal antibody formulations and cancer therapeutics. Despite these advances, challenges such as limited data availability, high operational costs, and the complexity of translating space findings to Earth\u2010based applications remain. 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