{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:18:28Z","timestamp":1790565508223,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    \u200cOleuropein (OLEU), a natural polyphenol, exhibits cardioprotective potential through mitochondrial modulation, yet its precise mechanisms remain elusive. This study elucidates OLEU's role in alleviating oxidative stress and regulating mitochondrial quality control via the PINK1\/Parkin pathway. In vitro, H9C2 cardiomyocytes exposed to H\u2082O\u2082\u2010induced oxidative stress were treated with OLEU (0\u2013200\u2009\u03bcM), and analyses included cell viability, ROS, SOD, MDA, \u0394\u03a8m, ATP, PINK1\/Parkin expression and detection of Mitophagic Flux. In vivo, myocardial infarction (MI) was induced in SD rats via coronary ligation, followed by OLEU administration, with assessments of cardiac function, histopathology, and mitophagy using echocardiography, electron microscopy, immunohistochemistry and immunofluorescence. Results showed that OLEU (\u2264200\u2009\u03bcM) dose\u2010dependently restored cell viability, reduced ROS, and normalized SOD\/MDA (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), while mitigating \u0394\u03a8m collapse and ATP depletion, indicating enhanced mitochondrial bioenergetics. OLEU upregulated PINK1\/Parkin, promoting mitophagic clearance of damaged mitochondria, and metabolomic analysis revealed modulation of arginine\/proline and lipid pathways. In MI rats, OLEU attenuated ROS, preserved myocardial structure, and improved cardiac function, supported by elevated mitophagy in electron microscopy. These findings demonstrate that OLEU protects cardiomyocytes by suppressing oxidative stress, stabilizing mitochondrial integrity, and activating PINK1\/Parkin\u2010mediated mitophagy, highlighting its therapeutic potential for myocardial injury and mitochondrial dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70171","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:23:24Z","timestamp":1758878604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1\/Parkin Signaling Pathway"],"prefix":"10.1002","volume":"86","author":[{"given":"Hao","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Cardiology the Second Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-3680","authenticated-orcid":false,"given":"Chunli","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Special Needs Ward and General Practice the Second Hospital of Jilin University Changchun 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