{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:17:17Z","timestamp":1789438637664,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Designing novel selenium\u2010containing compounds (organoselenium compounds, OSe) has shown growing interest owing to their chemoprotective and antioxidant properties. Consequently, by harnessing a fragment merging approach, a series of novel OSe hybrid compounds bearing selanyl phenyl acetamide and thiazolidinedione scaffolds were designed and synthesized (\n                    <jats:bold>8\u201310<\/jats:bold>\n                    ,\n                    <jats:bold>11a\u2013c<\/jats:bold>\n                    ,\n                    <jats:bold>12a\u2013c<\/jats:bold>\n                    ,\n                    <jats:bold>13a\u2013c<\/jats:bold>\n                    , and\n                    <jats:bold>14<\/jats:bold>\n                    ). The growth inhibition percentages (GI%) of the newly afforded OSe were evaluated using seven human cancer cells along with one normal cell line to ensure selectivity and safety. Interestingly, it was revealed that compound\n                    <jats:bold>9<\/jats:bold>\n                    exhibited the best mean GI% (75.54%), surpassing the doxorubicin (Dox) mean GI% of 72.28%. In addition, the inhibitory concentration 50 (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values of the frontier compounds\n                    <jats:bold>9<\/jats:bold>\n                    ,\n                    <jats:bold>13a<\/jats:bold>\n                    ,\n                    <jats:bold>13c<\/jats:bold>\n                    ,\n                    <jats:bold>12b<\/jats:bold>\n                    , and\n                    <jats:bold>12c<\/jats:bold>\n                    were assessed against cancer cell lines PC3, MCF7, and HCT\n                    <jats:sub>116<\/jats:sub>\n                    . Compound\n                    <jats:bold>13c<\/jats:bold>\n                    displayed the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    value (5.195\u2009\u00b5M) at the PC3 cancer cell line, surpassing doxorubicin (8.065\u2009\u00b5M). Besides, compounds\n                    <jats:bold>9<\/jats:bold>\n                    and\n                    <jats:bold>12c<\/jats:bold>\n                    revealed the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    values (21.045 and 13.575\u2009\u00b5M) against MCF7 and HCT\n                    <jats:sub>116<\/jats:sub>\n                    , respectively. Moreover, analogues\n                    <jats:bold>9<\/jats:bold>\n                    and\n                    <jats:bold>13c<\/jats:bold>\n                    were chosen to examine their ability to induce apoptosis and showed the upregulation of proapoptotic proteins: Caspases (3, 7, and 9) and BAX, besides the downregulation of the antiapoptotic BCL2, MMP2, and MMP9 proteins. Furthermore,\n                    <jats:italic>in silico<\/jats:italic>\n                    molecular docking studies targeting BCL\u20102, along with ADMET analyses, were performed. The results indicated that the tested compounds demonstrated favourable binding affinity to the selected target and exhibited acceptable pharmacokinetic properties. Consequently, these compounds can be considered promising lead candidates for inducing apoptosis in cancer cells, warranting further optimization.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70190","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:19:32Z","timestamp":1763367572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leveraging the Fragment Merging Approach for Synthetizing Novel Selanyl Phenyl Acetamide Thiazolidinedione Hybrids Endowed With Apoptotic Potential for Cancer Treatment"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-6926","authenticated-orcid":false,"given":"Saad","family":"Shaaban","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science King Faisal University  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-3039","authenticated-orcid":false,"given":"Ayman Abo","family":"Elmaaty","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department, Faculty of Pharmacy Port Said University  Port Said Egypt"},{"name":"Medicinal Chemistry Department, Clinical Pharmacy Program East Port Said National University  Port Said Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya Yaseen Mahmood","family":"Alabdali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy The University of Mashreq  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Ba\u2010Ghazal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Faisal University  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7894-3514","authenticated-orcid":false,"given":"Marwa","family":"Sharaky","sequence":"additional","affiliation":[{"name":"Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI) Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Alaa","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai A. E.","family":"Mourad","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department, Faculty of Pharmacy Port Said University  Port Said Egypt"},{"name":"Medicinal Chemistry Department, Clinical Pharmacy Program East Port Said National University  Port Said Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-8644","authenticated-orcid":false,"given":"Mohamed","family":"Alaasar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema Suliman","family":"Alatawi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-7646","authenticated-orcid":false,"given":"Tarek A.","family":"Yousef","sequence":"additional","affiliation":[{"name":"College of Science, Chemistry Department Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-3315","authenticated-orcid":false,"given":"Arwa Omar Al","family":"Khatib","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-6073","authenticated-orcid":false,"given":"Ahmed A.","family":"Al\u2010Karmalawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy The University of Mashreq  Baghdad Iraq"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Horus University\u2010Egypt  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70123"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conbuildmat.2022.130135"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-36222-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1338627"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241242635"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"1","article-title":"Nanotechnology in the Treatment of Infectious Diseases: A Review","volume":"19","author":"Alabdali A. 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