{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:58:20Z","timestamp":1789747100208,"version":"4.0.1"},"reference-count":165,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Proteolysis\u2010targeting chimeras (PROTACs)\u2010mediated protein degradation has been recently developed as a game\u2010changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation. PROTACs are different from regular small\u2010molecule inhibitors because they are heterobifunctional compounds that use the ubiquitin\u2010proteasome system to breakdown disease\u2010causing oncogenic proteins. This review discusses the next generation of PROTAC platforms that innovate beyond traditional designs, such as dual\u2010targeting PROTACS that present a novel mode of action, transcription factor\u2010targeting PROTACs (TF\u2010PROTACs), phosphorylation\u2010dependent PROTACs (PhosphoTACs), and phosphorylation binding chimeras (PhosTACs). In kinase degradation, PROTACs have shown promise in addressing resistance mechanisms and carcinogenic drivers. Despite these advancements, issues with clinical pharmacokinetics, E3 ligase tissue selectivity, and subcellular localization persist. Additionally, the development of bio\u2010responsive and spatially controlled PROTAC systems, such as photocaged and folate\u2010caged PROTACs, was fully discussed, which achieves maximal precision in tumor selectivity. Furthermore, ARV\u2010110 and ARV\u2010471, as two representative PROTACs, have entered clinical trials, suggesting their potentially broader application. Accordingly, this review provides a critical overview of the design rationales, molecular mechanisms of action, therapeutic utilities, and synthetic issues associated with these innovative modalities, focusing on on their translational implication and pharmacokinetic limitations, as well as potential future clinical applications.<\/jats:p>","DOI":"10.1002\/ddr.70192","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:10:47Z","timestamp":1765264247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Next\u2010Generation Proteolysis\u2010Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-6390","authenticated-orcid":false,"given":"Mohamed S.","family":"Nafie","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Sciences University of Sharjah Sharjah United Arab Emirates"},{"name":"Bioinformatics and Functional Genomics Research Group, Research Institute of Sciences and Engineering (RISE) University of Sharjah Sharjah United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-1357","authenticated-orcid":false,"given":"Mohamed K.","family":"Diab","sequence":"additional","affiliation":[{"name":"Pest Physiology Department Plant Protection Research Institute, Agricultural Research Center Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa S. A.","family":"Yassen","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Galala University  Egypt"},{"name":"Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany M.","family":"Elshamy","sequence":"additional","affiliation":[{"name":"Medical Laboratory Science Department, School of Allied Health Sciences Badr University in Cairo (BUC) Badr City Egypt"},{"name":"The Faculty of Healthcare Technology Saxony Egypt University for Applied Science &amp; Technology (SEU) Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R.","family":"El Tohamy","sequence":"additional","affiliation":[{"name":"Medical Laboratory Science Department, School of Allied Health Sciences Badr University in Cairo (BUC) Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-5716","authenticated-orcid":false,"given":"Haytham O.","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-8281","authenticated-orcid":false,"given":"Sherif Ashraf","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics Marburg University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2062338"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.4c00362"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.10.002"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mencom.2022.07.001"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-153575"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.4c00577"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17576180.2025.2481021"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cb00011j"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.707317"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.872729"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10320"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00220e"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01144"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.672267"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00901"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00693"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116972"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cs00762a"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400682"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011214"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16121649"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00387b"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22055"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.04.007"},{"key":"e_1_2_20_27_1","first-page":"169","volume-title":"Clinical Development of PROTACs, in: PROTAC\u2010Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics","author":"Dubey A.","year":"2024"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117872"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70401"},{"key":"e_1_2_20_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4dd00177j"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14361-z"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06348-2"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103395"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00200k"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01493"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01487"},{"key":"e_1_2_20_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102137"},{"key":"e_1_2_20_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-025-01137-5"},{"key":"e_1_2_20_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2024.2377530"},{"key":"e_1_2_20_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2022.101062"},{"key":"e_1_2_20_41_1","doi-asserted-by":"publisher","DOI":"10.15212\/amm-2022-0010"},{"key":"e_1_2_20_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00587"},{"key":"e_1_2_20_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21877"},{"key":"e_1_2_20_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00003"},{"key":"e_1_2_20_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.022"},{"key":"e_1_2_20_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00928-9"},{"key":"e_1_2_20_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-023-03104-z"},{"key":"e_1_2_20_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113922"},{"key":"e_1_2_20_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11706"},{"key":"e_1_2_20_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj7251"},{"key":"e_1_2_20_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202100270"},{"key":"e_1_2_20_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03125-5"},{"key":"e_1_2_20_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-022-04490-8"},{"key":"e_1_2_20_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.160606"},{"key":"e_1_2_20_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00253"},{"key":"e_1_2_20_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1434002"},{"key":"e_1_2_20_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.04.007"},{"key":"e_1_2_20_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01707-5"},{"key":"e_1_2_20_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2025.2463310"},{"key":"e_1_2_20_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2985"},{"key":"e_1_2_20_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-23-0719"},{"key":"e_1_2_20_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30102123"},{"key":"e_1_2_20_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00189"},{"key":"e_1_2_20_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02399-4"},{"key":"e_1_2_20_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116506"},{"key":"e_1_2_20_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105489"},{"key":"e_1_2_20_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00193d"},{"key":"e_1_2_20_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07535-x"},{"key":"e_1_2_20_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400161"},{"key":"e_1_2_20_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01434-3"},{"key":"e_1_2_20_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01258-8"},{"key":"e_1_2_20_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c01241"},{"key":"e_1_2_20_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00691"},{"key":"e_1_2_20_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02637"},{"key":"e_1_2_20_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21992"},{"key":"e_1_2_20_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202401051"},{"key":"e_1_2_20_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03852"},{"key":"e_1_2_20_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c00451"},{"key":"e_1_2_20_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00454"},{"key":"e_1_2_20_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05499"},{"key":"e_1_2_20_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-022-00112-0"},{"key":"e_1_2_20_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400109"},{"key":"e_1_2_20_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00150"},{"key":"e_1_2_20_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-022-00551-9"},{"key":"e_1_2_20_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2024.101172"},{"key":"e_1_2_20_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01242"},{"key":"e_1_2_20_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0md00272k"},{"key":"e_1_2_20_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216346"},{"key":"e_1_2_20_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.141273"},{"key":"e_1_2_20_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081948"},{"key":"e_1_2_20_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112993"},{"key":"e_1_2_20_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21774"},{"key":"e_1_2_20_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115444"},{"key":"e_1_2_20_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527836208.ch5"},{"key":"e_1_2_20_95_1","doi-asserted-by":"publisher","DOI":"10.15212\/amm-2024-0006"},{"key":"e_1_2_20_96_1","unstructured":"Mize B. K.2023. \u201cMedicinal Chemistry Drug Discovery Efforts Towards Anticancer Leads: The Development of CDK9\u2010Targeting PROTAC and PHY\u201034 Analogues.\u201d Doctor of Philosophy Ohio State University.http:\/\/rave.ohiolink.edu\/etdc\/view?acc_num=osu1681913524279521."},{"key":"e_1_2_20_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15014"},{"key":"e_1_2_20_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155611"},{"key":"e_1_2_20_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12199674"},{"key":"e_1_2_20_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01379-8"},{"key":"e_1_2_20_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01535-7"},{"key":"e_1_2_20_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105476"},{"key":"e_1_2_20_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00595"},{"key":"e_1_2_20_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10121368"},{"key":"e_1_2_20_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2254012"},{"key":"e_1_2_20_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.013"},{"key":"e_1_2_20_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02332"},{"key":"e_1_2_20_108_1","first-page":"1","volume-title":"Understanding the Ubiquitin Proteasome System: History and Revolution, in: PROTAC\u2010Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics","author":"Qadir A.","year":"2024"},{"key":"e_1_2_20_109_1","doi-asserted-by":"crossref","unstructured":"Rampeesa N. K. R.Gundla G.Muddasani et al.2024. \u201cNovel Azaspirooxindolinone\u2010Based PROTACs for Selective BTK Degradation and Enhanced Anticancer Activity.\u201dhttps:\/\/doi.org\/10.26434\/chemrxiv-2024-pxdtn-v2.","DOI":"10.26434\/chemrxiv-2024-pxdtn"},{"key":"e_1_2_20_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00136"},{"key":"e_1_2_20_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.05.010"},{"key":"e_1_2_20_112_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00339b"},{"key":"e_1_2_20_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00142"},{"key":"e_1_2_20_114_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-23-0747"},{"key":"e_1_2_20_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-97-5077-1_2"},{"key":"e_1_2_20_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01017"},{"key":"e_1_2_20_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52966-3"},{"key":"e_1_2_20_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-23-0655"},{"key":"e_1_2_20_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104032"},{"key":"e_1_2_20_120_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s448684"},{"key":"e_1_2_20_121_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00148a"},{"key":"e_1_2_20_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2025.2490248"},{"key":"e_1_2_20_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00358"},{"key":"e_1_2_20_124_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4md00252k"},{"key":"e_1_2_20_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17040501"},{"key":"e_1_2_20_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00195"},{"key":"e_1_2_20_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3164_411"},{"key":"e_1_2_20_128_1","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2020.00018"},{"key":"e_1_2_20_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000249"},{"key":"e_1_2_20_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911068"},{"key":"e_1_2_20_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.575"},{"key":"e_1_2_20_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01754-z"},{"key":"e_1_2_20_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02024-9"},{"key":"e_1_2_20_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129864"},{"key":"e_1_2_20_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030259"},{"key":"e_1_2_20_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116707"},{"key":"e_1_2_20_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00385-8"},{"key":"e_1_2_20_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107319"},{"key":"e_1_2_20_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c01036"},{"key":"e_1_2_20_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01908-w"},{"key":"e_1_2_20_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091257"},{"key":"e_1_2_20_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02032"},{"key":"e_1_2_20_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202421713"},{"key":"e_1_2_20_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2024.129778"},{"key":"e_1_2_20_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01312-w"},{"key":"e_1_2_20_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b06422"},{"key":"e_1_2_20_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113150"},{"key":"e_1_2_20_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00728"},{"key":"e_1_2_20_149_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3cb00199g"},{"key":"e_1_2_20_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.679120"},{"key":"e_1_2_20_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.129041"},{"key":"e_1_2_20_152_1","doi-asserted-by":"publisher","DOI":"10.1080\/17576180.2025.2459528"},{"key":"e_1_2_20_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217112"},{"key":"e_1_2_20_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104994"},{"key":"e_1_2_20_155_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0sc01676d"},{"key":"e_1_2_20_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308049"},{"key":"e_1_2_20_157_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124744"},{"key":"e_1_2_20_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02624"},{"key":"e_1_2_20_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00089"},{"key":"e_1_2_20_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400171"},{"key":"e_1_2_20_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00649"},{"key":"e_1_2_20_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413376"},{"key":"e_1_2_20_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01530"},{"key":"e_1_2_20_164_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1ob01613j"},{"key":"e_1_2_20_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70133"},{"key":"e_1_2_20_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01266-z"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:52:28Z","timestamp":1765525948000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":165,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ddr.70192"],"URL":"https:\/\/doi.org\/10.1002\/ddr.70192","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70192"}}