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Recent therapeutic advances have increasingly focused on integrating targeted therapy, immunotherapy, and chemotherapy with nanodrug delivery systems (NDDS) to enhance treatment efficacy. Chemotherapy remains a cornerstone, with optimized regimens improving outcomes while reducing systemic toxicity. Immunotherapy (including checkpoint inhibitors, adoptive T\u2010cell transfer, and CAR\u2010T cell therapy) has demonstrated promising clinical potential. Targeted therapy disrupts key molecular pathways critical for tumor progression, offering a more selective approach with fewer adverse effects. NDDS amplify these strategies by improving drug bioavailability, enabling sustained and controlled release, enhancing tumor penetration, and overcoming drug resistance within the bone tumor microenvironment. They also facilitate the co\u2010delivery of multiple agents for synergistic effects. 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