{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:26:24Z","timestamp":1791915984331,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sudden death resulting from abdominal aortic aneurysm (AAA) rupture is a highly fatal cardiovascular condition. There remains an urgent need to identify innovative therapeutic strategies capable of decelerating AAA progression and rupture. Although polydatin (PLD) has been consistently shown to exert potent anti\u2010inflammatory effects in diverse pathological contexts, its regulatory role in AAA has not yet been investigated. Using a porcine pancreatic elastase (PPE) infusion\u2013induced AAA mouse model, we comprehensively evaluated PLD's influence on NRF2 signaling by Western blot (WB) analysis, immunohistochemistry (IHC), immunofluorescence (IF), flow cytometry (FC), and real\u2010time quantitative PCR (RT\u2010qPCR) tests. Our findings demonstrate that PLD robustly activates NRF2 pathway, thereby attenuating AAA formation by curbing smooth muscle cell (SMCs) phenotypic transformation and apoptosis, as well as suppressing macrophage\u2010mediated inflammatory responses.<\/jats:p>","DOI":"10.1002\/ddr.70223","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:13:18Z","timestamp":1767589998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polydatin Protects Against the Formation of PPE\u2010Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2\u2010Related Factor 2"],"prefix":"10.1002","volume":"87","author":[{"given":"Zikang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Jingzhou Central Hospital Affiliated to Yangtze University Jingzhou City Hubei Province 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