{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:13:07Z","timestamp":1789438387272,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lung cancer remains a leading cause of cancer\u2010related mortality, and resistance to platinum\u2010based chemotherapy necessitates the development of alternative metal\u2010based therapeutics. In this study, two iridium(III) complexes were synthesized and systematically investigated for their photophysical and biological properties. Spectroscopic characterisation confirmed effective ligand coordination and metal\u2010to\u2010ligand charge transfer behaviour. Both complexes exhibited significant interaction with calf thymus DNA, with intrinsic binding constants of 5.01\u2009\u00d7\u200910\n                    <jats:sup>4\u2009<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.08\u2009\u00d7\u200910\n                    <jats:sup>4\u2009<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and showed strong affinity towards human serum albumin (K\n                    <jats:sub>HSA<\/jats:sub>\n                    up to 8.30\u2009\u00d7\u200910\n                    <jats:sup>6\u2009<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Antioxidant activity assessed by the DPPH assay revealed moderate radical scavenging ability. Cytotoxicity studies using an MTT assay demonstrated concentration\u2010dependent antiproliferative activity against A549 lung cancer cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 57.6\u2009\u00b5M and 36.0\u2009\u00b5M, while maintaining low toxicity towards normal HEK 293 cells.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70225","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:35:15Z","timestamp":1768293315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iridium(III) Complexes for Lung Cancer Therapy: Recent Advances and Case Studies in DNA Targeting, Antioxidant Activity and Cytotoxicity"],"prefix":"10.1002","volume":"87","author":[{"given":"Bhumika","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Advance Science VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010sciences School of Bio Sciences and Technology VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatraman","family":"Manickam","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010sciences School of Bio Sciences and Technology VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-0719","authenticated-orcid":false,"given":"Murugesh","family":"Shivashankar","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Advance Science VIT University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4DT00171K"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600831213"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/CHEM.202500290"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES27041326"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLSTRUC.2020.129413"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JINORGBIO.2023.112145"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT04045C"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACSPTSCI.2C00115"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/B107656F"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLSTRUC.2023.136017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA06269A"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACSOMEGA.3C04867"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113206660288"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TC00568K"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DYEPIG.2021.109925"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00775-023-01997-0"},{"key":"e_1_2_9_18_1","unstructured":"Lung cancer statistics | World Cancer Research Fund. 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