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Mutations in TP53, particularly missense mutations, have a substantial impact on cancer progression because they give gain\u2010of\u2010function features that enhance proliferation, metastasis, and treatment resistance. This review examines the mechanisms underlying p53 mutations, including their interactions with critical regulatory circuits, and assesses novel medication and prodrug options targeting\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations in various malignancies. Small\u2010molecule correctors, statins, Hsp90 inhibitors, and new drugs like Eprenetapopt and COTI\u20102 are among the therapeutic options proposed. The mechanisms of action and potential efficacy in treating leukemia, lung, breast, and ovarian malignancies are investigated. Emerging techniques for restoring wild\u2010type p53 functionality or degrading mutant p53 demonstrate the therapeutic potential of these approaches. Challenges such as medication resistance, side effects, and the chemical complexity of p53 pathways are also addressed, emphasizing the importance of ongoing research. This review contributes to our understanding of TP53\u2010targeted cancer medicines, offering hope for more innovative treatments with improved outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70246","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:38:26Z","timestamp":1770727106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-429X","authenticated-orcid":false,"given":"Raed M.","family":"Al\u2010Zoubi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, QU\u2010Health, College of Health Sciences Qatar University Doha Qatar"},{"name":"Department of Surgery, Hamad Medical Corporation Surgical Research Section Doha Qatar"},{"name":"Department of 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