{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:13:36Z","timestamp":1786119216156,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of quinazoline derivatives\n                    <jats:bold>5\u201319<\/jats:bold>\n                    bearing a benzenesulfonamide moiety and different acetamide side chains, including aromatic and heterocyclic groups, were designed, synthesized and confirmed structurally by microanalytical and spectral data. The obtained compounds were evaluated in vitro for their ability to activate nuclear factor erythroid 2\u2010related factor 2 (Nrf2) through induction of NAD(P)H: quinone oxidoreductase 1 (NQO1) in Hepa1c1c7 murine hepatoma cells. Compounds\n                    <jats:bold>15<\/jats:bold>\n                    and\n                    <jats:bold>18<\/jats:bold>\n                    exhibited the highest potency with CD values of 2.5 and 5\u2009\u00b5M, respectively. The most potent derivatives (\n                    <jats:bold>15<\/jats:bold>\n                    and\n                    <jats:bold>18<\/jats:bold>\n                    ) were further evaluated for their antioxidant potential using DPPH, with compound\n                    <jats:bold>18<\/jats:bold>\n                    demonstrating the highest radical scavenging activity. A radiation\u2010based biodistribution study was conducted using\n                    <jats:bold>18<\/jats:bold>\n                    and displayed marked selectivity toward tumor cells over normal cells. Molecular docking studies and molecular dynamics simulations demonstrated that\n                    <jats:bold>18<\/jats:bold>\n                    exhibits a strong binding affinity and forms key stabilizing interactions within the Nrf2\u2010binding domain of Kelch\u2010like ECH\u2010associated protein 1 (Keap1). These results demonstrate that quinazoline sulfonamide derivatives are promising oxidative stress modulators with tumor targeting ability.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70274","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:25:18Z","timestamp":1775021118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Antioxidant Quinazoline Sulfonamide Derivatives Acting Through NQO1 Induction and Their Radiation\u2010Based Biodistribution Studies"],"prefix":"10.1002","volume":"87","author":[{"given":"Mostafa M.","family":"Ghorab","sequence":"first","affiliation":[{"name":"Department of Drug Radiation Research National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-9828","authenticated-orcid":false,"given":"Aiten M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Drug Radiation Research National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Higgins","sequence":"additional","affiliation":[{"name":"Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine University of Dundee Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albena T.","family":"Dinkova\u2010Kostova","sequence":"additional","affiliation":[{"name":"Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine University of Dundee Scotland UK"},{"name":"Department of Pharmacology and Molecular Sciences and Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Amin","sequence":"additional","affiliation":[{"name":"Labeled Compounds Department Hot Labs Center, Egyptian Atomic Energy Authority Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Korany","sequence":"additional","affiliation":[{"name":"Labeled Compounds Department Hot Labs Center, Egyptian Atomic Energy Authority Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Khedr","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Helwan University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer M.","family":"Sakr","sequence":"additional","affiliation":[{"name":"Radioactive Isotopes and Generator Department Hot Labs Center, Egyptian Atomic Energy Authority Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139082"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118187"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13184"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.08.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.03.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071255"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121476"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103312"},{"key":"e_1_2_9_10_1","first-page":"243","volume-title":"Methods Enzymol","author":"Fahey J. 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