{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:13:43Z","timestamp":1786119223272,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Drugs with multiple anticancer mechanisms have shown promising applications in tumor treatment. Herein, we synthesized a series of ferrocene\u2010pyrazole hybrids (\n                    <jats:bold>8<\/jats:bold>\n                    \u2013\n                    <jats:bold>11<\/jats:bold>\n                    ) to assess their anti\u2010pancreatic cancer activities. Among them, compound\n                    <jats:bold>11<\/jats:bold>\n                    exhibited higher anti\u2010cancer effects compared to other compounds and showed low toxicity to normal HK\u20102 cells. The hemolysis experiment shows that compound\n                    <jats:bold>11<\/jats:bold>\n                    exhibited low hemolytic activity. Proteomics and metabolomics studies have found that a total of 35 proteins and 58 metabolites (negative mode) showed significantly different abundances in BxPC\u20103 cells treated with 10\u2009\u03bcM compound\n                    <jats:bold>11<\/jats:bold>\n                    . Subsequent research unveiled that compound\n                    <jats:bold>11<\/jats:bold>\n                    eradicates pancreatic cancer cells through the activation of various mechanisms, including ferroptosis and metabolic pathways. These studies may stimulate the development of ferrocene\u2010pyrazole hybrids and provide effective cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70280","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:55:16Z","timestamp":1775814916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferrocene\u2013Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer"],"prefix":"10.1002","volume":"87","author":[{"given":"Kuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Center of Respiratory Medicine The First Affiliated Hospital of Guilin Medical University Guilin China"},{"name":"Key Laboratory of Basic Research in Respiratory Diseases Health Commission of Guangxi Zhuang Autonomous Region Guilin China"},{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, 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