{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:08:22Z","timestamp":1792458502987,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH080"],"award-info":[{"award-number":["ZR2020QH080"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Senile osteoporosis is driven by bone marrow stromal cell (BMSC) senescence. Ferroptosis, an iron\u2010dependent cell death pathway, is implicated in aging. The natural flavonoid galangin possesses anti\u2010aging properties, yet its effects on ferroptosis and BMSC senescence are unknown. Natural aging and\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose\u2010induced aging models were used, with galangin supplementation. Bone mass was assessed via micro\u2010computed tomography and histomorphometry. Senescence markers (P21, SA\u2010\u03b2\u2010gal, NAD+) and ferroptosis regulators (GPX4, GSH\/GSSG) were measured. BMSC senescence was induced by\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose or serial passaging. Effects of galangin on senescence, ferroptosis, osteogenic differentiation, and dipeptidyl peptidase\u20104 (DPP4) signaling were evaluated. Galangin significantly attenuated bone loss and reduced senescence markers in both aging mouse models. Ferroptosis was activated in senescent BMSC. Galangin suppressed ferroptosis, rescued senescence phenotypes, and restored osteogenic differentiation capacity. Mechanistically, galangin inhibited DPP4 nuclear translocation and disrupted its interaction with NADPH oxidase NOX1, thereby blocking reactive oxygen species\u2010dependent ferroptosis signaling without altering total DPP4 expression. Galangin ameliorates Senile osteoporosis by specifically inhibiting DPP4 nuclear translocation and its interaction with NOX1, thereby suppressing ferroptosis, rescuing BMSC senescence, and restoring osteogenic function. This identifies galangin as a promising agent against skeletal aging.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70295","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:02:02Z","timestamp":1777291322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["DPP4\u2010Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age\u2010Related Bone Loss"],"prefix":"10.1002","volume":"87","author":[{"given":"Hongming","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China"},{"name":"Department of Spinal Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital Jinan China"},{"name":"Department of Spine Surgery Linyi Central Hospital Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of First Clinical Medical Shandong University of Traditional Chinese Medicine Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengren","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China"},{"name":"Department of Spinal Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 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