{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T13:03:46Z","timestamp":1779714226287,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Breast cancer (BC), characterized by a high incidence specifically in women, exhibits a complex etiology. This study aims to investigate the role and underlying mechanism of\n                      <jats:italic>microrchidia CW\u2010type zinc finger 2 (MORC2)<\/jats:italic>\n                      in BC progression. MCF\u20107 and MDA\u2010MB\u2010231 cells with\n                      <jats:italic>MORC2<\/jats:italic>\n                      knockdown were utilized to investigate the impact of\n                      <jats:italic>MORC2<\/jats:italic>\n                      on BC. To explore the in vivo functions of\n                      <jats:italic>MORC2,<\/jats:italic>\n                      xenograft tumor mouse model was established. In this study, we discovered that\n                      <jats:italic>MORC2<\/jats:italic>\n                      was significantly upregulated in BC tumor tissues. Consistent with MORC2 functioning as a suppressor of pyroptosis,\n                      <jats:italic>MORC2<\/jats:italic>\n                      knockdown enhanced the expression of pyroptosis\u2010related markers (Caspase\u20101, NLRP3, GSDMD\u2010N, and LDH) and inflammatory factors (IL\u201018, IL\u20101\u03b2, and TNF\u2010\u03b1), while suppressing\n                      <jats:italic>CCL5, CCL2<\/jats:italic>\n                      levels, and macrophage migration. Furthermore,\n                      <jats:italic>MORC2<\/jats:italic>\n                      knockdown inhibited tumor growth in vivo, decreased CD68 cell infiltration and M2 markers, and increased the M1\/M2 macrophage ratio. TAMs from\n                      <jats:italic>MORC2\u2010<\/jats:italic>\n                      knockdown tumors exhibited reduced immunosuppressive capacity, promoting T cell proliferation and IFN\u2010\u03b3\/IL\u20102 production. Mechanistically, silencing of\n                      <jats:italic>MORC2<\/jats:italic>\n                      suppressed the\n                      <jats:italic>Wnt\/\u03b2\u2010catenin<\/jats:italic>\n                      pathway, and Compound 3\u2009f significantly reversed the effects of\n                      <jats:italic>MORC2<\/jats:italic>\n                      knockdown on pyroptosis and macrophage recruitment BC. In summary, MORC2 suppresses pyroptosis and promotes TAMs recruitment in BC;\n                      <jats:italic>MORC2<\/jats:italic>\n                      knockdown alleviated the progression of BC by reversing these effects, which was mediated by suppressing the\n                      <jats:italic>Wnt\/\u03b2\u2010catenin<\/jats:italic>\n                      signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ddr.70300","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:11:56Z","timestamp":1779095516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>MORC2<\/i>\n                    Recruits Tumor\u2010Associated Macrophages and Inhibits Pyroptosis Through Activating the\n                    <i>Wnt\/\u03b2\u2010Catenin<\/i>\n                    Pathway in Breast Cancer"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-7626","authenticated-orcid":false,"given":"Zhiyong","family":"Liu","sequence":"first","affiliation":[{"name":"Breast Treatment Center the First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hu","sequence":"additional","affiliation":[{"name":"Breast Treatment Center the First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Breast Treatment Center the First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8570-5828","authenticated-orcid":false,"given":"Xiaoshan","family":"Meng","sequence":"additional","affiliation":[{"name":"Breast Treatment Center the First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33408"},{"issue":"17","key":"e_1_2_12_3_1","article-title":"Countering Triple Negative Breast Cancer Via Impeding Wnt\/\u03b2\u2010Catenin Signaling, A Phytotherapeutic Approach","volume":"11","author":"Arzi L.","year":"2022","journal-title":"Plants (Basel, 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