{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:45:31Z","timestamp":1791787531919,"version":"4.3.4"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mesalamine (5\u2011aminosalicylic acid, mesalazine, or 5\u2011ASA) remains a cornerstone therapy for mild\u2011to\u2011moderate ulcerative colitis because of its local anti\u2011inflammatory and antioxidant actions on the intestinal mucosa, and its clinical performance has increasingly been refined through advances in synthetic medicinal chemistry and drug\u2011delivery science. Beyond conventional formulations, medicinal chemistry efforts have explored mesalamine analogues and hybrid molecules, including prodrug approaches and conjugates with anti\u2011inflammatory or redox\u2011modulating moieties, to extend target engagement beyond classical cyclooxygenase inhibition toward pathways such as oxidative stress regulation and inflammasome signaling, thereby offering the potential for synergistic, multi\u2011pathway control of mucosal inflammation. In parallel, nanoparticle\u2011based delivery systems\u2014such as pH\u2011responsive polymeric nanoparticles, mucoadhesive nanocarriers, and multi\u2011matrix or hydrogel\u2011based platforms\u2014have been developed to protect mesalamine from premature upper gastrointestinal absorption, exploit disease\u2011associated pH and permeability changes, and prolong residence time at inflamed colonic sites, resulting in higher local drug concentrations with reduced systemic exposure. These strategies complement established oral and topical formulations and combination regimens, with preclinical and early translational data suggesting improvements in mucosal healing, attenuation of oxidative injury, and enhanced adherence through simplified dosing. When viewed together with emerging combination strategies that pair mesalamine with agents such as budesonide, sucralfate, or antioxidant and immunomodulatory compounds, these advances underscore a broader shift toward precision\u2011designed mesalamine therapies, integrating molecular optimization and targeted delivery to improve clinical outcomes in ulcerative colitis and to support exploratory roles in related inflammatory enteropathies.<\/jats:p>","DOI":"10.1002\/ddr.70321","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:26Z","timestamp":1779340046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesalamine in Treatment of Intestinal Inflammatory Diseases\u2014Formulation\u2010Driven Strategies for Targeted Colonic Therapy and Remission Maintenance"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2200-1545","authenticated-orcid":false,"given":"Bijayananda","family":"Sahoo","sequence":"first","affiliation":[{"name":"Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University) Sawangi (Meghe) Wardha Maharashtra India"},{"name":"Alembic Pharmaceuticals Limited Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1039-8648","authenticated-orcid":false,"given":"Jitendra","family":"Patel","sequence":"additional","affiliation":[{"name":"Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University) Sawangi (Meghe) Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02969351"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90676-G"},{"issue":"4","key":"e_1_2_14_4_1","first-page":"406","article-title":"Ulcerative Colitis: Rapid Evidence Review","volume":"105","author":"Adams S. M.","year":"2022","journal-title":"American Family Physician"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.18.s2.1.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224234"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy166"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab010"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26217"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.037"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1666101"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.230091"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S35691"},{"issue":"1","key":"e_1_2_14_14_1","first-page":"55","article-title":"Role of Sucralfate in Gastrointestinal Diseases","volume":"42","author":"Candelli M.","year":"2000","journal-title":"Panminerva Medica"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70262"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.70246"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.07.002"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02938-6"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000473"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2024.2397650"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531372"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12712"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i34.5665"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.07.005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.410"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad920e"},{"issue":"8","key":"e_1_2_14_27_1","first-page":"1188","article-title":"Mesalamine Capsules for Treatment of Active Ulcerative Colitis: Results of a Controlled Trial. Pentasa Study Group","volume":"88","author":"Hanauer S.","year":"1993","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2015.1118493"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125547"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500177880"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56100515"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/18722113113079990014"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39401-0"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.009"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.02.000152"},{"key":"e_1_2_14_37_1","first-page":"1301","article-title":"Effects of Mesalazine on the Formation of Lipoxygenase and Cyclooxygenase Products","volume":"371","author":"Lauritsen K.","year":"1995","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18030312"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA08622A"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-024-04711-x"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-021-02295-6"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000853"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.195"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.04.016"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027893"},{"issue":"3","key":"e_1_2_14_46_1","first-page":"181","article-title":"Residual Inflammation and Ulcerative Colitis in Remission","volume":"10","author":"Moss A. C.","year":"2014","journal-title":"Gastroenterology & Hepatology"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144734"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01008-6"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20797"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30231-0"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa127"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04620.x"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2021.1968813"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i17.4846"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312464"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.016"},{"issue":"12","key":"e_1_2_14_58_1","first-page":"A5307","article-title":"Epidemiologic and Therapeutic Aspects of Refractory Coeliac Disease\u2014A Systematic Review","volume":"63","author":"Rowinski S. A.","year":"2016","journal-title":"Danish Medical Journal"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx032"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21567"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2596-8934"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2596-8934"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073001"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802600961"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092905"},{"issue":"4","key":"e_1_2_14_68_1","article-title":"Oral 5\u2010Aminosalicylic Acid for Maintenance of Remission in Ulcerative Colitis","author":"Sutherland L.","year":"2002","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02724-w"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00438.x"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i15.2068"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00350"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12362"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-3927"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11405250"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-31910-5"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89620-x"}],"updated-by":[{"DOI":"10.1002\/ddr.70393","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000}}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.70321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:26:39Z","timestamp":1791354399000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ddr.70321"],"URL":"https:\/\/doi.org\/10.1002\/ddr.70321","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2026-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70321"}}