{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:09Z","timestamp":1790776869218,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4\u2010naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties. Selenium, an essential trace element, has shown significant potential in medicinal chemistry when incorporated into organic molecules. In this study, we synthesized 24 novel selenium\u2010containing derivatives based on menadione (series A) and 1,4\u2010naphthoquinone (series B), incorporating selenium as selenoester and selenocyanate functionalities. Initial cytotoxic screening at 25 and 10\u2009\u00b5M against four cancer cell lines (MDA\u2010MB\u2010231, PC\u20103, HTB\u201054 and HCT\u2010116) identified five active compounds, with\n                    <jats:bold>B2<\/jats:bold>\n                    and\n                    <jats:bold>B8<\/jats:bold>\n                    exhibiting the highest potency and selectivity against breast cancer cells. Further biological evaluation via the NCI Developmental Therapeutics Program confirmed their apoptosis induction and antiproliferative activity through reactive oxygen species (ROS) production. Molecular dynamics simulations additionally suggest that\n                    <jats:bold>B2<\/jats:bold>\n                    and\n                    <jats:bold>B8<\/jats:bold>\n                    may act as topoisomerase II alpha inhibitors. These results position compounds\n                    <jats:bold>B2<\/jats:bold>\n                    and\n                    <jats:bold>B8<\/jats:bold>\n                    as promising candidates for breast cancer therapy, paving the way for further investigation into their potential as chemotherapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70332","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:30:16Z","timestamp":1781771416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selenium\u2010Containing 1,4\u2010Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple\u2010Negative Breast Cancer Cells"],"prefix":"10.1002","volume":"87","author":[{"given":"Eduardo","family":"Angulo\u2010Elizari","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Penn State Cancer Institute, CH72, Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Penn State Cancer Institute, CH72, Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Mart\u00ednez\u2010S\u00e1ez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Enc\u00edo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA) Pamplona 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