{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:09Z","timestamp":1790776869758,"version":"4.1.0"},"reference-count":112,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370993"],"award-info":[{"award-number":["32370993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173764"],"award-info":[{"award-number":["82173764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CSTB2025NSCQ\u2010GPX0624"],"award-info":[{"award-number":["CSTB2025NSCQ\u2010GPX0624"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The relentless rise of antimicrobial resistance poses a critical threat to global health, urgently demanding the development of antibacterial vaccines. Messenger RNA (mRNA) technology, validated during the COVID\u201019 pandemic, offers a powerful platform of fast development and flexibility. However, its application against bacterial pathogens remains an emerging frontier due to the structural complexity of bacterial antigens, challenges in achieving effective mucosal and cellular delivery, and the need to elicit balanced Th1\/Th17\u2010dominated immune responses for durable protection. Progress in antigen design, mRNA engineering, and lipid nanoparticle (LNP) delivery has enabled early preclinical success against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    . Yet, challenges such as complex antigen expression, mucosal targeting, and immune durability persist. This review provides a brief overview of recent advances in bacterial mRNA vaccine design, including antigen selection, mRNA engineering, and delivery platform optimization. Additionally, we summarize current preclinical progress across key bacterial pathogens and highlight emerging strategies that integrate AI\u2010guided antigen discovery, synthetic biology, and next\u2010generation delivery systems to accelerate clinical translation. Finally, we highlight the prospects of bacterial mRNA vaccines by integrating synthetic biology, AI\u2010driven antigen prediction, and advanced delivery systems. These cutting\u2010edge technologies hold the promise of overcoming existing barriers, ultimately establishing mRNA vaccines as a viable and powerful strategy to curb the tide of antibiotic\u2010resistant infections.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70335","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:42:09Z","timestamp":1781865729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance"],"prefix":"10.1002","volume":"87","author":[{"given":"Rui","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Southwest Hospital Third Military Medical University  Chongqing Chongqing China"},{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"},{"name":"Department of Pediatrics Ludwig\u2010Maximilians University  Munich Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fating","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ludwig\u2010Maximilians University  Munich Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2991-1112","authenticated-orcid":false,"given":"Shan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Southwest Hospital Third Military Medical University  Chongqing Chongqing China"},{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Southwest Hospital Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Southwest Hospital Third Military Medical University  Chongqing Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-02070-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0114-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI190736"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59353-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.12.044"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad502"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2543983"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128924"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.02.013"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.04.043"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.10.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad502"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-01033-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.03.060"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00283-5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312559"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.05.005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00702.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024671"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjvaccines.2016.12"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.011"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00466-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0390-6"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TBTB2-0018-2016"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S244081"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2018.09.003"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00497-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-025-01244-4"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07343"},{"key":"e_1_2_12_31_1","first-page":"1","article-title":"mRNA\u2010Based Vaccines and Mode of Action","volume":"440","author":"Gergen J.","year":"2022","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"e_1_2_12_32_1","unstructured":"Global Burden of Bacterial Antimicrobial Resistance 1990\u20132021: A Systematic Analysis With Forecasts to 2050. Lancet (London England)2024 404 (10459) 1199\u20131226."},{"key":"e_1_2_12_33_1","unstructured":"Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis. Lancet (London England)2022 399 (10325) 629\u2013655."},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0829"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53969-w"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0358-x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105487"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux011"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236074"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2023.1207380"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0505-4"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adu1493"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NH00217A"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1355245"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_12_48_1","doi-asserted-by":"crossref","unstructured":"Kawaguchi K. M.Kinoshita K.Sudo et al.2023.mRNA Vaccine Induces Protective Immunity Against the Type III Secretory Virulence ofPseudomonas aeruginosaPreprint bioRxiv June 10.https:\/\/doi.org\/10.1101\/2023.06.09.544431.","DOI":"10.1101\/2023.06.09.544431"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113860"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252313139"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-023-00844-z"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202870109"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00811-9"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg1036"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12111267"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00446-2"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/narmme\/ugaf045"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11010130"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.015"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00583-2"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.11.009"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28776-w"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300669"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116611"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk2444"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145501"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105599"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.41"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.03.039"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00506-3"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2024.2333123"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.027"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.818669"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81083"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02110-9"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317216"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S241064"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3322"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171450"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05482-0"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6481-9_6"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020306"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08466-x"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.70212"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125623"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3818"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1179"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.10.017"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.03.038"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018778713"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3239-0_27"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1271143"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1247041"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0229-2"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176144"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.03.016"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.09.008"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01214"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1188754"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0485"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.1994.11718380"},{"issue":"4","key":"e_1_2_12_105_1","first-page":"277","article-title":"The Antibiotic Resistance Crisis: Part 1: Causes and Threats","volume":"40","author":"Ventola C. L.","year":"2015","journal-title":"P & T: A Peer\u2010reviewed Journal for Formulary Management"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1540359"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00672-4"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.103755"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.11.009"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652321403140819122538"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.024"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00461-z"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163731"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.70335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.70335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.70335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:35:29Z","timestamp":1790775329000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.70335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":112,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ddr.70335"],"URL":"https:\/\/doi.org\/10.1002\/ddr.70335","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70335"}}