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Propylene glycol was chosen as co\u2010surfactant, Tween 80 as surfactant, and peppermint oil as oil phase after excipients screening, as this combination exhibited the broadest emulsification region in pseudo\u2010ternary phase diagram. A systematic Quality\u2010by\u2010Design (QbD) approach was adopted, and formulation variables were optimized using Design\u2010Expert software to obtain an optimized L\u2010SNEDDS formulation with desirable physicochemical attributes. Dilution of the optimized SNEDDS led to the spontaneous formation of a stable aqueous nanoemulsion exhibiting a droplet size of 110.9\u2009nm, polydispersity index (PDI) 0.265, transmittance of 98.86\u2009\u00b1\u20090.37%, zeta potential of \u221216.3\u2009mV, viscosity of 6.35\u2009\u00b1\u20092.51\u2009cP, self\u2010emulsification time of 27.35\u2009s, and conductivity of 196.23\u2009\u00b1\u20090.324 \u03bcS cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    . In vivo studies showed that SEL\u2010BCA\u2010loaded SNEDDS exhibited better oral bioavailability than pure SEL\u2010BCA suspension. Notably, SNEDDS achieved higher brain C\n                    <jats:sub>max<\/jats:sub>\n                    values for SEL (5.6\u2009\u00b1\u20090.41\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and BCA (13.84\u2009\u00b1\u20091.14\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), as well as elevated plasma concentrations of SEL (6.51\u2009\u00b1\u20090.43\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and BCA (762.65\u2009\u00b1\u200916.82\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Collectively, the results underscore the potential of the SEL\u2010BCA SNEDDS as a combinational delivery platform that could improve the effectiveness of combination therapy for the management of PD.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70342","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:00:04Z","timestamp":1783321204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design\u2010Expert Assisted Formulation Development, Optimization, and Evaluation of Selegiline and Biochanin A Loaded Self\u2010Nanoemulsifying Drug Delivery System"],"prefix":"10.1002","volume":"87","author":[{"given":"Shivani","family":"Tyagi","sequence":"first","affiliation":[{"name":"Faculty of Medicine &amp; Health Sciences, SRM Institute of Science and Technology, Delhi\u2010NCR Campus SRM Modinagar College of Pharmacy Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6651-6371","authenticated-orcid":false,"given":"Jayendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Health Sciences, SRM Institute of Science and Technology, Delhi\u2010NCR Campus SRM Modinagar College of Pharmacy Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2017.09.042"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41120-017-0016-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2021.618411\/FULL"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.05.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2020.105035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.03.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1359862"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21093243"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367892"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDDST.2022.103117"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.11.045"},{"key":"e_1_2_8_13_1","unstructured":"Current controversies in the use of selegiline hydrochloride. 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