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By integrating a selective phenoxyacetic acid moiety. Our findings identified compound\n                    <jats:bold>7c<\/jats:bold>\n                    as a potential lead candidate for the development of novel anticonvulsant agents. In vivo trials demonstrated that\n                    <jats:bold>7c<\/jats:bold>\n                    offers a superior therapeutic window compared to valproic acid, yielding 90% seizure protection in PTZ models and a remarkable 212.27% delay in seizure onset within the pilocarpine model, alongside 100% survival. Beyond mere symptomatic suppression,\n                    <jats:bold>7c<\/jats:bold>\n                    re\u2010engineers the hippocampal environment by slashing glutamate\u2010driven excitotoxicity by 64.23% and silencing the cytokine\u2010glial activation axis (TNF\u2010alpha, IL\u20106, GFAP, and Iba\u20101). Supported by ADME profile confirming optimal BBB permeability and molecular docking indicating a robust binding affinity of \u221210.3\u2009kcal\/mol, this study positions\n                    <jats:bold>7c<\/jats:bold>\n                    as a versatile, non\u2010toxic, and repurposed\u2010ready hybrid candidate for advanced neuroprotective intervention.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70363","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:15Z","timestamp":1786978035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Phenoxyacetic Acid Hybrids With COX\u20102 Inhibitory Activity as Potential Anti\u2010Neuroinflammatory Agents"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-9111","authenticated-orcid":false,"given":"Mohammad 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