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Ferroptosis and N\u2010methyl\u2010D\u2010aspartate (NMDA) receptor activity,may be interconnected in the pathogenesis of A\u03b2 accumulation and associated neurodegeneration in AD. However, the interplay between these pathways remains poorly understood and underexplored for therapeutic intervention against the AD. The review aims to explore the shared molecular triggers of ferroptosis and NMDA receptor overactivation, including the roles of iron, glutamate overload, calcium dysregulation, and reactive oxygen species (ROS) accumulation. We further highlighted the convergent consequences of these processes on mitochondrial dysfunction, lipid peroxidation, and their impact on A\u03b2 pathology. Particular attention is given to P\u2010glycoprotein (P\u2010gp), an efflux transporter involved in the A\u03b2 clearance at the blood\u2013brain barrier, whose expression and function may be modulated by oxidative stress, iron homeostasis, and NMDA receptor signaling. Emerging evidence indicated that ferroptosis and NMDA receptor activity may disrupt P\u2010gp function, thereby impairing A\u03b2 clearance and promoting its accumulation in the AD. Overall, the review elucidates the molecular mechanisms linking ferroptosis and NMDA receptor overactivation and their impact on P\u2010gp\u2010mediated A\u03b2 transport in the AD, providing integrated mechanisms and harnessing their potential for AD therapeutics.<\/jats:p>","DOI":"10.1002\/ddr.70367","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:50:14Z","timestamp":1787154614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis and NMDA Receptor Activity in Alzheimer's Disease: Implications for Amyloid Pathology and P\u2010Glycoprotein Regulation"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2139-8478","authenticated-orcid":false,"given":"Jotiram","family":"Salunkhe","sequence":"first","affiliation":[{"name":"R. C. 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