{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:06:15Z","timestamp":1789027575033,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>SND1 is an oncoprotein found to be overexpressed in breast cancer, especially in triple\u2010negative breast cancer(TNBC). In our previous study, a novel SND1\u2010interacting peptide 4\u20102 was identified, exhibiting cytotoxicity to TNBC cells by inducing SND1 degradation. This study for the first time demonstrated the degradation of SND1 was proteasome\u2010dependent. A series of peptide 4\u20102 derivatives were constructed using PROTAC technology. Among these, 4\u20102 VHL\u2010recruiting PROTAC showed significantly increased SND1 degradation efficiency and higher anticancer activity to TNBC cells. The in vivo efficacy study suggested the D\u2010isoform of 4\u20102VHL PROTAC suppressed the growth of TNBC cells in xenograft mouse model more effectively than peptide 4\u20102. Mechanistically, 4\u20102 VHL\u2010recruiting PROTAC was demonstrated to induce pyroptosis of TNBC cells through Fas\u2010mediated IL\u201017signaling. This study provides a new lead compound for the development of theSND1\u2010targeted therapy via the proteolysis\u2010targeting system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ddr.70377","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:41:06Z","timestamp":1788417666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["4\u20102 VHL\u2010Recruiting PROTAC Inhibits the Growth and Migration of Triple Negative Breast Cancer Cells by Triggering Pyroptosis Through Fas\u2010Mediated IL\u201017 Signaling"],"prefix":"10.1002","volume":"87","author":[{"given":"Qiqi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Food and Drug Shenzhen Polytechnic University Shenzhen Guangdong China"},{"name":"Shenzhen Hospital Southern Medical University Shenzhen Guangdong 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