{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:49:11Z","timestamp":1791791351427,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cholinergic dysfunction is a key feature of cognitive impairment, and currently available acetylcholinesterase (AChE) inhibitors provide limited symptomatic benefit and are often associated with adverse effects. This study evaluated the cognitive\u2010protective effects of bavachin (BVC), a prenylated flavonoid from Psoralea corylifolia, and its interaction with Donepezil (DNP) in a scopolamine (SCP)\u2010induced amnesia model. Male Swiss albino mice were pretreated with BVC (10\u201340\u2009mg\/kg), DNP (2.5\u2009mg\/kg), or their combination for 7 days prior to SCP challenge, followed by assessment using multiple behavioral paradigms, including novel object recognition, elevated plus maze, passive avoidance, Y\u2010maze, and Morris water maze. BVC attenuated SCP\u2010induced memory deficits in a dose\u2010dependent manner, with the 40\u2009mg\/kg dose producing performance statistically comparable to, though not formally demonstrated to be equivalent to, the normal control across tests. Bliss independence analysis of behavioral endpoints indicated predominantly additive interactions, with occasional greater\u2010than\u2010additive trends. Biochemical evaluation demonstrated that BVC inhibits AChE in vitro (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 27.7\u2009\u00b5M) and attenuates SCP\u2010induced elevations of AChE activity ex vivo in the frontal cortex and hippocampus. Combination treatment showed a greater\u2010than\u2010additive interaction in the frontal cortex (\u0394Bliss = 0.054) and an approximately additive effect in the hippocampus (\u0394Bliss = 0.013). Molecular docking and molecular dynamics simulations further suggested stable binding of BVC within the active sites of AChE and butyrylcholinesterase (BChE). Collectively, these findings indicate that BVC attenuates cognitive deficits, at least in part, through cholinesterase inhibition, and exhibits additive effects with DNP, supporting its potential as an adjunctive candidate for cognitive disorders.\n                  <\/jats:p>","DOI":"10.1002\/ddr.70394","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:29:26Z","timestamp":1791556166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bavachin Attenuates Cognitive Impairment in Scopolamine\u2010Induced Amnesia: Behavioral, Biochemical and Molecular Insights"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1587-2838","authenticated-orcid":false,"given":"Md.","family":"Shadin","sequence":"first","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd. Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monisha Brati","family":"Barua","sequence":"additional","affiliation":[{"name":"Animal Science and Veterinary Medicine Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-841X","authenticated-orcid":false,"given":"Talat","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Services, College of Applied Medical Sciences, Khamis Mushait Campus King Khalid University (KKU) Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9691-1600","authenticated-orcid":false,"given":"Farha","family":"Farahim","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Nursing, College of Nursing, Khamis Mushait Campus King Khalid University (KKU) Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Ripon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehedi Hasan","family":"Linkon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Shakil","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4426-2808","authenticated-orcid":false,"given":"Mohammed","family":"Alfaifi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-1631","authenticated-orcid":false,"given":"Faisal H.","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences University of Tabuk Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-2537","authenticated-orcid":false,"given":"Abdullah H.","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Faculty of Medicine University of Tabuk Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-9636","authenticated-orcid":false,"given":"Faisal","family":"Alsenani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Umm Al\u2010Qura University Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3820","authenticated-orcid":false,"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd. 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