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Using various methodologies including retrospective studies, community samples, and sibling cohorts, researchers have identified behavioral markers of the disorder that emerge over the first 2 years of life. However, there are characteristics of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> that overlap with other types of developmental delay (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>), which may complicate differential diagnosis in young children. A review of the literature was conducted to identify the most promising behavioral markers that distinguish <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> from other types of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> in the first 2 years of life. The review identified profiles of behavioral markers in the social realm by 12 months and in the communication realm by 18 months, which along with additional atypical motor behaviors could distinguish <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. This constellation of features coupled with a flat or declining trajectory in specific aspects of social and communication development, may assist clinicians in targeting early interventions to at\u2010risk infants. \u00a9 2013 Wiley Periodicals, Inc. 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