{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:15:13Z","timestamp":1793128513719,"version":"4.5.0"},"reference-count":88,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T00:00:00Z","timestamp":1288137600000},"content-version":"vor","delay-in-days":299,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Disabil Res Revs"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The primary focus of pain research in intellectually disabled individuals is still on pain assessment. Several observational pain assessment scales are available, each with its own characteristics, its own target group and its own validated use. Observational studies report differences in the treatment of intra\u2010 and postoperative pain of intellectually disabled children and almost all children with intellectual disability have comorbidities that need to be addressed. The scope of research has started to broaden. In this review we aim to answer the question: Can we integrate validated ways of pain assessment and postoperative pain treatment in intellectually disabled children to develop specific analgesic algorithms? Regrettably there is little knowledge on possible interaction effects and other relevant pharmacological issues. Possible genotype\u2013phenotype associations related to pain in children with Down syndrome have several promises as six possible candidate genes are located on chromosome 21. In conclusion, the pain assessment tools for intellectually disabled children are there. We should now focus on tailoring the pain treatment. To this aim we need to perform pharmacokinetic and pharmacodynamic studies of analgesics and obtain information about the genotype\u2013phenotype relationships for pain. This can lead to the development of specific analgesic algorithms. \u00a9 2010 Wiley\u2010Liss, Inc. Dev Disabil Res Rev 2010;16:248\u2013257.<\/jats:p>","DOI":"10.1002\/ddrr.117","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T12:50:21Z","timestamp":1288183821000},"page":"248-257","source":"Crossref","is-referenced-by-count":28,"title":["Pain management in intellectually disabled children: Assessment, treatment, and translational research"],"prefix":"10.1002","volume":"16","author":[{"given":"Abraham J.","family":"Valkenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"de Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes N.","family":"van den Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03135-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.02.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0854"},{"key":"e_1_2_8_5_1","first-page":"CD005399","article-title":"Pharmacological interventions for epilepsy in people with intellectual disabilities","author":"Beavis J","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181b27c4c"},{"key":"e_1_2_8_7_1","first-page":"359","article-title":"Pain insensitivity and indifference: alternative explanations for some medical catastrophes","volume":"29","author":"Biersdorff KK","year":"1991","journal-title":"Ment Retard"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.01.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02238.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.03.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/642352"},{"key":"e_1_2_8_13_1","first-page":"149","volume-title":"Pain in children and adults with developmental disabilities","author":"Breau LM","year":"2006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.019778"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20393"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4871.1128"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181773b69"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-004-1033-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-3101"},{"key":"e_1_2_8_21_1","article-title":"The role of population PK\u2010PD modelling in paediatric clinical research","author":"De Cock RF","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3104\/reprints.293"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00650.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004703-199908000-00005","article-title":"Children with cognitive impairment: parent report of pain and coping","volume":"20","author":"Fanurik D","year":"1999","journal-title":"J Dev Behav Pediatr"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199912000-00007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335490712200109"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181634867"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.01110.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02419.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1998.00764.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02433.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b852"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00239-X"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(08)34065-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.188"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90901-5"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012518"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03259-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00428.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035092"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3104\/reports.2009"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2009.18.7.41656"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948060-00003"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328339250b"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.07.005"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.01.006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.04.041"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.02980.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21691"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70112-5"},{"key":"e_1_2_8_52_1","first-page":"1","article-title":"Quantitative sensory testing in the German research network on neuropathic pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes","author":"Maier C","year":"2010","journal-title":"Pain"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acpain.2005.01.002"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00686.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199904060-00039"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f35f19"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.1995.tb00331.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.09.010"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(02)00013-1"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02619.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122012832"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20136"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20164"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.07.001"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.03.016"},{"key":"e_1_2_8_67_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1192\/bjp.104.435.434","article-title":"Reactions of low\u2010grade mental defectives to pain","volume":"104","author":"Stengel E","year":"1958","journal-title":"J Ment Sci"},{"key":"e_1_2_8_68_1","first-page":"67","volume-title":"Pain in neonates and infants","author":"Stevens BJ","year":"2007"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3283183fe4"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922007921"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.11.011"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010123431515"},{"key":"e_1_2_8_73_1","first-page":"193","volume-title":"Pain in children and adults with developmental disabilities","author":"Taddio A","year":"2006"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005584"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00453-0"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847040-00002"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1213\/01ANE.0b013e3181ba43b2"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03321600"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000261521.52562.de"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2009.01158.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287680.21212.d0"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2009.08.006"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1253-0"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.09.045"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181dcd5a0"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2007.00970.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2006.00917.x"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31816c8929"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.11.009"}],"container-title":["Developmental Disabilities Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddrr.117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddrr.117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:35:15Z","timestamp":1694507715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ddrr.117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/ddrr.117"],"URL":"https:\/\/doi.org\/10.1002\/ddrr.117","archive":["Portico"],"relation":{},"ISSN":["1940-5510","1940-5529"],"issn-type":[{"value":"1940-5510","type":"print"},{"value":"1940-5529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}