{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:38Z","timestamp":1791125618926,"version":"4.1.0"},"reference-count":130,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:00:00Z","timestamp":1224028800000},"content-version":"vor","delay-in-days":288,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Disabil Res Revs"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard\u2010risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment\u2010related neuropsychological sequelae represents the next major challenge in pediatric ALL. \u00a9 2008 Wiley\u2010Liss, Inc. Dev Disabil Res Rev 2008;14:185\u2013195.<\/jats:p>","DOI":"10.1002\/ddrr.24","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T07:13:28Z","timestamp":1224141208000},"page":"185-195","source":"Crossref","is-referenced-by-count":38,"title":["Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment"],"prefix":"10.1002","volume":"14","author":[{"given":"Laura A.","family":"Janzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda J.","family":"Spiegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.6.476"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950190607"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.84"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880019009033410"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2454"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199022000-00009"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80343-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80333-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/23.5.333"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199612000-00004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199910000-00013"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20397"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617705050666"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/18.3.319"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.12.2621"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20860"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0904"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsj114"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540220031012"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20113"},{"issue":"3","key":"e_1_2_1_22_1","first-page":"S45","article-title":"Long\u2010term neuropsychological risks in pediatric bone marrow transplant: what do we know?","volume":"18","author":"Cool VA","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/13.2.183"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.10.2826"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1988.tb00757.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21364"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsj074"},{"key":"e_1_2_1_28_1","first-page":"53","volume-title":"Cognitive reserve: theory and applications","author":"Dennis M","year":"2007"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1200\/JCO.1991.9.6.1029","article-title":"Absence of synergistic effects of CNS treatments on neuropsychologic test performance among children","volume":"9","author":"Dowell RE","year":"1991","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565648909540419"},{"key":"e_1_2_1_31_1","first-page":"442","article-title":"Neurocognitive late effects in adult survivors of childhood acute lymphoblastic leukemia (abstract)","volume":"22","author":"Edelstein K","year":"2008","journal-title":"Clin Neuropsychol"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.5.391"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.7.525"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/26.1.1"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.857"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)91020-N"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90976-O"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2608::AID-CNCR28>3.0.CO;2-L"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199706)28:6<387::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/22.6.861"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390600813841"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3180f61b92"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10999"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-198106000-00002"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92997-1"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.12.953"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.06.014"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.051839"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1076\/chin.10.1.14.26240"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1859::AID-CNCR28>3.0.CO;2-2"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.4505"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199305000-00012"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117066"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200202000-00010"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.10.1286"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700699"},{"key":"e_1_2_1_57_1","first-page":"447","article-title":"A prospective study of cognitive functioning following low\u2010dose cranial radiation for bone marrow transplantation","volume":"90","author":"Kramer JH","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880301)61:5<928::AID-CNCR2820610512>3.0.CO;2-O"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010601123281"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.047"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00432-K"},{"key":"e_1_2_1_62_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1200\/JCO.1984.2.5.359","article-title":"Treatment of meningeal relapse in childhood acute lymphoblastic leukemia. I. Results of craniospinal irradiation","volume":"2","author":"Kun LE","year":"1984","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10055"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1561"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.18.3273"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2006-002"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540260060017"},{"key":"e_1_2_1_68_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1017\/S0317167100047934","article-title":"Severe permanent encephalopathy in acute lymphoblastic leukemia","volume":"20","author":"Maria BL","year":"1993","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2 <1079::AID-CNCR2820370815>3.0.CO;2-D"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91216-2"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20147"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11117"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05509.x"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/15.7.603"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200020901"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911101)68:9<1913::AID-CNCR2820680912>3.0.CO;2-2"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800407313268"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.Supplement_2.S28"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90257-6"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.8.1348"},{"key":"e_1_2_1_81_1","first-page":"31","volume-title":"Late effects of treatment for childhood cancer","author":"Mulhern RK","year":"1992"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.7.1095"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.60.3.477"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.6.933"},{"key":"e_1_2_1_85_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1200\/JCO.1988.6.2.315","article-title":"Memory function in disease\u2010free survivors of childhood acute lymphocytic leukemia given CNS prophylaxis with or without 1,800 cGy cranial irradiation","volume":"6","author":"Mulhern RK","year":"1988","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600942769"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-04-02047.1994"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.1.145"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.5.622"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21544"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.5.1004"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1158"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035091"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70070-6"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023001"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/25.2.59"},{"key":"e_1_2_1_98_1","first-page":"2371","article-title":"A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation","volume":"26","author":"Reddick WE","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_1_99_1","first-page":"1263","article-title":"Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high\u2010dose methotrexate","volume":"26","author":"Reddick WE","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21679"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.10.1245"},{"key":"e_1_2_1_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199012000-00004"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.14.2.189"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704102075"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018909014573"},{"key":"e_1_2_1_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12<2285::AID-CNCR10>3.0.CO;2-Q"},{"key":"e_1_2_1_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200202000-00011"},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.11.003"},{"key":"e_1_2_1_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.145"},{"key":"e_1_2_1_110_1","first-page":"17","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20101995","author":"Smith MA","year":"1999"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507172930303"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9055"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-198408000-00005"},{"key":"e_1_2_1_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/8.1.47"},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.12.3.237"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/12.3.395"},{"key":"e_1_2_1_117_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.13.1.76"},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.12.949"},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(95)00191-3"},{"key":"e_1_2_1_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00260-5"},{"key":"e_1_2_1_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200005000-00004"},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/15.1.105"},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.173"},{"key":"e_1_2_1_124_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.10.2490"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.5.810"},{"key":"e_1_2_1_126_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.8464"},{"key":"e_1_2_1_127_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1984.02140460022009"},{"key":"e_1_2_1_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/1.2.183"},{"key":"e_1_2_1_129_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.1.2052695"},{"key":"e_1_2_1_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.4.252"},{"key":"e_1_2_1_131_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2740"}],"container-title":["Developmental Disabilities Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddrr.24","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddrr.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:57:59Z","timestamp":1694617079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ddrr.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":130,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/ddrr.24"],"URL":"https:\/\/doi.org\/10.1002\/ddrr.24","archive":["Portico"],"relation":{},"ISSN":["1940-5510","1940-5529"],"issn-type":[{"value":"1940-5510","type":"print"},{"value":"1940-5529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}