{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:08:30Z","timestamp":1790676510297,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Disabil Res Revs"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mathematical learning disabilities (MLD) occur frequently in children with specific genetic disorders, like Turner syndrome, fragile X syndrome and neurofibromatosis. This review focuses on MLD in children with chromosome 22q11.2 deletion syndrome (22q11DS). This syndrome is the most common known microdeletion syndrome with a prevalence of at least 1:4000 to 1:6000 live births. Although the clinical presentation of 22q11DS is quite variable, its major characteristics include velopharyngeal abnormalities, congenital cardiac anomalies, mild facial dysmorphism and learning difficulties. Children with 22q11DS show considerable difficulties in mathematics, despite relatively normal reading performance. While fact retrieval seems to be preserved, impairments in procedural calculation and word problem solving are particularly prominent. Children with 22q11DS also have substantial difficulties in understanding and representing numerical quantities, possibly related to poor visuospatial attention, which all might stem from their underlying abnormalities in the inferior parietal cortex. This review ends with a discussion on how research on genetic disorders might aid our understanding of MLD in general. \u00a9 2009 Wiley\u2010Liss, Inc. Dev Disabil Res Rev 2009;15:4\u201310.<\/jats:p>","DOI":"10.1002\/ddrr.44","type":"journal-article","created":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T06:34:13Z","timestamp":1234420453000},"page":"4-10","source":"Crossref","is-referenced-by-count":61,"title":["Mathematical learning disabilities in children with 22q11.2 deletion syndrome: A review"],"prefix":"10.1002","volume":"15","author":[{"given":"Bert","family":"De Smedt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Swillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Verschaffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Ghesqui\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70504-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000183905.23396.f1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)02040-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.020"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.09.013"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2008.02.005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.9.1700"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl097"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.23.4.447.1228"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2007.03.007"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.101"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/jecp.1996.2358"},{"key":"e_1_2_1_15_1","volume-title":"The mathematical brain","author":"Butterworth B","year":"1999"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2008.04.002"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2007.00955.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cortex.2007.06.003","article-title":"2009. Basic number processing and difficulties in single\u2010digit arithmetic: evidence from velo\u2010cardio\u2010facial syndrome","volume":"45","author":"De Smedt B","journal-title":"Cortex"},{"key":"e_1_2_1_20_1","first-page":"259","article-title":"Mathematical disabilities in young children with velo\u2010cardio\u2010facial syndrome","volume":"17","author":"De Smedt B","year":"2006","journal-title":"Genet Couns"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.08.024"},{"key":"e_1_2_1_22_1","first-page":"71","article-title":"Cognitive correlates of mathematical disabilities in children with velo\u2010cardio\u2010facial syndrome","volume":"19","author":"De Smedt B","year":"2008","journal-title":"Genet Couns"},{"key":"e_1_2_1_23_1","volume-title":"The number sense: how the mind creates mathematics","author":"Dehaene S","year":"1997"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290244000239"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.54"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.1.125"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00011"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.409"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.3"},{"key":"e_1_2_1_30_1","first-page":"119","volume-title":"Syndrome of nonverbal learning disabilities: neurodevelopmental manifestations","author":"Fuerst KB","year":"1995"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/00222194040370010201"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.537"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1572"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.9"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecresq.2004.01.012"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.9.1701"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01002-7"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2003.11.004"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/35098574"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2006.00791.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235651100"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.52"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.50"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/jecp.1999.2516"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70415-4"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.5.397"},{"key":"e_1_2_1_47_1","first-page":"397","article-title":"Rote numeric skills may mask underlying mathematical disabilities in girls with fragile\u2010X syndrome","volume":"179","author":"Murphy MM","year":"2008","journal-title":"Dev Neuropsychol"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2005.01460.x"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.5"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544101.003"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.10.013"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2007.01131.x"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi055"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.045"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2006.01.005"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90734-K"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.903576"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:2<142::AID-MRDD9>3.0.CO;2-H"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.2"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195077872.001.0001"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.8"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70889-X"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579405050364"},{"key":"e_1_2_1_64_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.7551\/mitpress\/4946.003.0010","volume-title":"Neurogenetic developmental disorders","author":"Simon TJ","year":"2007"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.018"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.08.016"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297040590911167"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1006\/jecp.2000.2587"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.6.453"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<531::AID-AJMG20>3.0.CO;2-L"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1076\/0929-7049(199912)05:04;1-R;FT230"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00125.x"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00008"}],"container-title":["Developmental Disabilities Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddrr.44","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddrr.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:43:23Z","timestamp":1694493803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ddrr.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/ddrr.44"],"URL":"https:\/\/doi.org\/10.1002\/ddrr.44","archive":["Portico"],"relation":{},"ISSN":["1940-5510","1940-5529"],"issn-type":[{"value":"1940-5510","type":"print"},{"value":"1940-5529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}