{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:48:17Z","timestamp":1753868897808,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Capsule endoscopy (CE) has been shown to have poor diagnostic performance when the capsule passes quickly through the small bowel, especially the proximal jejunum. This study aimed to evaluate the diagnostic yield of proximal jejunal lesions with third\u2010generation CE technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined 138 consecutive patients, 76 (55.0%) of whom were men. The patients\u2019 median age was 70 years, and proximal jejunal lesions were detected by CE and\/or double\u2010balloon endoscopy at Hiroshima University Hospital between January 2011 and June 2021. We analyzed the diagnostic accuracy of CE for proximal jejunal lesions and compared the characteristics of the discrepancy between the use of CE and double\u2010balloon endoscopy with Pillcam SB 2 (SB2) and Pillcam SB 3 (SB3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SB2 and SB3 were used in 48 (35%) and 90 (65%) patients, respectively. There was no difference in baseline characteristics between these groups. Small\u2010bowel lesions in the proximal jejunum comprised 75 tumors (54%), 50 vascular lesions (36%), and 13 inflammatory lesions (9%). The diagnostic rate was significantly higher in the SB3 group than in the SB2 group for tumors (91%\u00a0vs. 72%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and vascular lesions (97%\u00a0vs. 69%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). For vascular lesions, in particular, the diagnostic rate of angioectasia improved in the SB3 group (100%) compared with that in the SB2 group (69%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SB3 use improved the detection of proximal jejunal tumors and vascular lesions compared with SB2 use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.134","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T04:53:10Z","timestamp":1655095990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic yield of proximal jejunal lesions with third\u2010generation capsule endoscopy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-4148","authenticated-orcid":false,"given":"Issei","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-0743","authenticated-orcid":false,"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Sumioka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Iio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Center for Integrated Medical Research Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kotachi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yuge","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[{"name":"Division of Regeneration and Medicine Center for Translational and Clinical Research Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013140"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.112181"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i7.666"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.02.027"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.07.029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.06.026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/915463"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5496242"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.06.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.01.005"},{"key":"e_1_2_7_13_1","first-page":"955","article-title":"Diagnostic yield of capsule endoscopy vs double\u2010balloon endoscopy for patients who have undergone total enteroscopy with obscure gastrointestinal bleeding","volume":"59","author":"Shishido T","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0110-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.12.242"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.06.008"},{"key":"e_1_2_7_17_1","unstructured":"Medtronic. PillCam SB3 Product Brochure.2018. [Cited 13 Oct 2021.] Available from URL:https:\/\/www.medtronic.com\/covidien\/en\u2010us\/products\/capsule\u2010endoscopy\/pillcam\u2010sb\u20103\u2010system.html"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9671327"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307263.127"},{"key":"e_1_2_7_20_1","first-page":"3066","article-title":"PillCam\u00ae SB3 capsule: Does the increased frame rate eliminate the risk of missing lesions?","volume":"22","author":"Monteiro S","year":"2016","journal-title":"World J Gastrointest Endosc"},{"key":"e_1_2_7_21_1","first-page":"155","article-title":"Capsule endoscopy with PillCamSB2 versus PillCamSB3: Has the improvement in technology resulted in a step forward?","volume":"110","author":"Xavier S","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12883"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/623208"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.9043"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.04.007"},{"key":"e_1_2_7_26_1","first-page":"1127","article-title":"Small bowel masses found and missed on capsule endoscopy for obscure bleeding","volume":"42","author":"Baichi M","year":"2007","journal-title":"Gastrointest Endosc"},{"key":"e_1_2_7_27_1","first-page":"1600","article-title":"Advance of video capsule endoscopy and the detection of anatomic landmarks","volume":"56","author":"Nakamura M","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.022"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12423"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.584899"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.10.016"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13507"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.025"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.054"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.04.080"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13575"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12280"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:44:56Z","timestamp":1747295096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/deo2.134"],"URL":"https:\/\/doi.org\/10.1002\/deo2.134","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"type":"print","value":"2692-4609"},{"type":"electronic","value":"2692-4609"}],"subject":[],"published":{"date-parts":[[2022,6,12]]},"assertion":[{"value":"2022-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e134"}}