{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:15:28Z","timestamp":1791504928072,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herein, we describe a case of olmesartan\u2010related sprue\u2010like enteropathy in which improvement in villous atrophy was confirmed by small\u2010bowel capsule endoscopy (CE). We successfully treated a 66\u2010year\u2010old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea 10 times a day and experienced a weight loss of 9 kg in 3 months. An abdominal computed tomography scan showed fluid retention in the small intestine. Blood test results revealed no inflammatory reaction. Esophagogastroduodenoscopy detected villous atrophy in the stomach and duodenum. Moreover, small\u2010bowel CE showed villous atrophy in about two\u2010thirds of the small intestine. Based on other examinations, hyperthyroidism, intestinal tuberculosis, intestinal amyloidosis, and intestinal malignant lymphoma were ruled out. Therefore, the patient was suspected of having an olmesartan\u2010related sprue\u2010like disease. Early after discontinuation of medication, diarrhea symptoms improved, and a repeat CE indicated improvements in small intestinal villous atrophy. Since the patient had been administered olmesartan for a long time and CE showed villous atrophy throughout the small bowel, we suspected him of having the olmesartan\u2010associated sprue\u2010like disease. The findings of gastric mucosa atrophy on esophagogastroduodenoscopy may lead to an early diagnosis of this disease. Olmesartan\u2010related sprue\u2010like enteropathy should be considered as a differential diagnosis in patients with chronic severe watery diarrhea.<\/jats:p>","DOI":"10.1002\/deo2.142","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T07:19:35Z","timestamp":1655536775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A case report of olmesartan\u2010associated sprue\u2010like enteropathy: Diagnosis and healing confirmed by capsule endoscopy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-7951","authenticated-orcid":false,"given":"Yoshiharu","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tajimi City Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Ebi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Funaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Kasugai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.06.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.7388"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01926-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-021-01514-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4336-19"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2006.2.4.327"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10R05FM"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12780"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-12-4-230"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.02.024"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:45:24Z","timestamp":1747295124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,18]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/deo2.142"],"URL":"https:\/\/doi.org\/10.1002\/deo2.142","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,18]]},"assertion":[{"value":"2022-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e142"}}