{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:35:18Z","timestamp":1772991318833,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Endoscopic ultrasonography is an important examination for periampullary diseases. The duodenum is filled with water to ensure a clear image and distend the duodenal wall without burying the papilla within duodenal folds; however, peristalsis frequently makes it difficult to maintain water within the duodenum. The gel immersion method (intestine is filled with viscosity gel) has recently been attracting attention. We evaluated the usefulness of using this method for endoscopic ultrasonography to detect and delineate the major duodenal papilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine consecutive patients who underwent gel immersion\u2010endoscopic ultrasonography between February and March 2021 were included retrospectively. The papilla was observed by filling the duodenum with clear viscosity gel. Outcomes were the rate of duodenal distention, delineation rates of the papilla, the time required for delineation, volume of the gel used, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Duodenal distention was excellent, good, and poor in 58%, 34%, and 7% of cases, respectively. The delineation rates of the papilla in the axial and longitudinal views were 98% and 66%, respectively. The median time required to delineate the papilla in each view was 3.1 (range, 1.0\u20131.4) and 7.9 (1.9\u201328.6) min; the median volume of the gel used was 80 (30\u2013150) ml and 100 (50\u2013200) ml, respectively. No adverse events were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gel immersion\u2010endoscopic ultrasonography provided sufficient duodenal distention, leading to high rates of detection and delineation of the papilla using a small volume of gel within a short time. This method may be useful for the evaluation of the ampullary region.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.158","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T05:39:44Z","timestamp":1659677984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of gel immersion endoscopic ultrasonography for delineating the duodenal papilla and pancreatobiliary ducts: A retrospective study with video"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-3665","authenticated-orcid":false,"given":"Haruka","family":"Toyonaga","sequence":"first","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Kin","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-4684","authenticated-orcid":false,"given":"Kosuke","family":"Iwano","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-3730","authenticated-orcid":false,"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Chikugo","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-4703","authenticated-orcid":false,"given":"Tatsuya","family":"Ishii","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nasuno","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"},{"name":"Department of Community Medicine, Section of Clinical Epidemiology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-5215","authenticated-orcid":false,"given":"Akio","family":"Katanuma","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2003.03142.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12234"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i27.4316"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v2.i8.278"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.09.048"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.01.028"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.10.027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13923"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780471462422.eoct631"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000230392.83607.c5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1408-0458"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14065"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1377384"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2017.098"},{"key":"e_1_2_7_17_1","volume-title":"Handbook of Inter\u2010rater Reliability: The Definitive Guide to Measuring the Extent of Agreement among Raters","author":"Gwet KL","year":"2014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1348\/000711006X126600"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:45:14Z","timestamp":1747295114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/deo2.158"],"URL":"https:\/\/doi.org\/10.1002\/deo2.158","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e158"}}