{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:39:11Z","timestamp":1785407951197,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chemoradiotherapy (CRT) or radiotherapy (RT) alone is often the treatment of choice for elderly patients with esophageal cancer with the expectation of organ preservation. However, salvage treatment remains a problem when endoscopic resection is not indicated for local failure after CRT\/RT. Photodynamic therapy (PDT) is indicated for local failure after CRT\/RT, but there are few reports on its efficacy and safety in elderly patients. This study aimed to assess the outcome of PDT for local failure after CRT\/RT for esophageal cancer in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective single\u2010center study included 42 patients who first underwent PDT between April 2013 and June 2021. Patients aged \u226580 and &lt;80 years were classified into the elderly and nonelderly groups, respectively. Local complete response rate, overall survival, progression\u2010free survival, and incidence of adverse events related to PDT were compared retrospectively between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The local complete response rate was 93.3% in the elderly group and 85.7 in the non\u2010elderly group. The 2\u2010year overall survival rate was 68.6% and 72.5%, and the 2\u2010year progression\u2010free survival rate was 49.5% and 70.0% in the elderly and nonelderly groups, respectively. There was no significant difference in any of these outcomes between the groups. In terms of adverse events, pneumonia and delirium tended to occur more frequently in the elderly group, but there were no serious adverse events in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcome of salvage PDT in the local control was comparable between the elderly and nonelderly patients for local failure after CRT\/RT for esophageal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.167","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T04:18:44Z","timestamp":1664165924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of photodynamic therapy as a salvage treatment for local failure after chemoradiotherapy or radiotherapy for esophageal cancer in patients aged 80 years or older"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-3583","authenticated-orcid":false,"given":"Michiko","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Kushida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syunta","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takegawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kakogawa Central City Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Tsumura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuya","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Oesophagus cancer fact sheet [Internet]. World Health Organization International Agency for Research on Cancer GLOBOCAN; 2020 [Cited 2022 May 20]. Available from:https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6\u2010Oesophagus\u2010fact\u2010sheet.pdf."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-018-0641-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199206113262403"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00585-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz208"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14029"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-06846-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13730"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051509"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00799-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256373"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.11.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-019-00690-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00725-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-021-00853-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14072"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.10.013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00750-9"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:44:19Z","timestamp":1747295059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/deo2.167"],"URL":"https:\/\/doi.org\/10.1002\/deo2.167","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]},"assertion":[{"value":"2022-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e167"}}