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An 86\u2010year\u2010old man with a history of abdominoperineal resection of the rectum for rectal cancer underwent resection with ESD for early\u2010stage sigmoid cancer 5 cm away from the stoma opening. At the same time, ileocecal resection was performed for advanced cecal cancer. Twelve months after ESD, advanced cancer occurred in the area of the ESD lesion. It was unclear if the cancer was a local recurrence after ESD, implantation of cecal cancer, or a new lesion. Copy number variation analysis performed for the three lesions revealed that the new lesion originated from residual tumor cells from ESD and was unlikely to be cecal cancer.<\/jats:p>","DOI":"10.1002\/deo2.208","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T06:56:32Z","timestamp":1675234592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Local recurrence of submucosal invasive colorectal cancer after endoscopic submucosal dissection revealed by copy number variation"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-8804","authenticated-orcid":false,"given":"Yu","family":"Okazawa","sequence":"first","affiliation":[{"name":"Department of Coloproctological Surgery Juntendo University Faculty of Medicine  Tokyo 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