{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:34:15Z","timestamp":1790436855623,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic balloon dilation (EBD) is an effective, minimally invasive treatment for Crohn's disease (CD) related intestinal strictures. However, restenosis frequently occurs and requires repetitive EBD or surgical resection. Since previous studies could not evaluate restenosis based on stricture diameter, factors affecting restenosis after EBD were unclear. This study aimed to identify these factors by precisely measuring the diameter of small intestinal strictures in patients with CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study enrolled patients with CD with de novo small intestinal strictures who underwent two double\u2010balloon enteroscopy sessions (EBD and follow\u2010up) between January 2016 and October 2021. Clinical and endoscopic data were obtained from electronic medical records. A calibrated small\u2010caliber\u2010tip transparent hood was used to precisely measure stricture diameters. Multivariate analysis was performed to identify factors associated with restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients (37 male) were analyzed. The total number of strictures detected decreased from 162 to 143. The mean diameter of all strictures and the narrowest stricture in each patient increased significantly from 8.6 to 9.8 mm and from 7.6 to 8.7 mm, respectively. Thirty\u2010two (67%) patients developed endoscopic restenosis. Multivariate analysis showed that the presence of ulcers at the follow\u2010up session was a risk factor for restenosis (odds ratio 9.4, <jats:italic>p<\/jats:italic> = 0.01). Patients with complete mucosal healing at both sessions (<jats:italic>n<\/jats:italic> = 21) showed significant improvement in the narrowest stricture (+1.7 mm, <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maintenance of complete mucosal healing is significantly associated with avoiding restenosis after EBD in CD\u2010related small intestinal strictures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.239","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T06:27:08Z","timestamp":1681799228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Maintenance of complete mucosal healing is associated with avoiding restenosis after endoscopic balloon dilation of Crohn's disease\u2010related small intestinal strictures"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-7947","authenticated-orcid":false,"given":"Ulzii","family":"Dashnyam","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"},{"name":"Department of Pediatrics Mongolian National University of Medical Sciences  Ulaanbaatar Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-2944","authenticated-orcid":false,"given":"Manabu","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-432X","authenticated-orcid":false,"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-1693","authenticated-orcid":false,"given":"Hirotsugu","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-9941","authenticated-orcid":false,"given":"Makiko","family":"Mieno","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Center for Information Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-7661","authenticated-orcid":false,"given":"Jun","family":"Owada","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-9304","authenticated-orcid":false,"given":"Kunihiko","family":"Oguro","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7257-0219","authenticated-orcid":false,"given":"Tsevelnorov","family":"Khurelbaatar","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi Japan"},{"name":"Endoscopy Center, Mongolian Japan Hospital Mongolian National University of Medical Sciences  Mongolia Ulaanbaatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keijiro","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi 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endoscopic balloon dilations using a calibrated small\u2010caliber\u2010tip transparent hood for a patient with 10 ileal strictures secondary to Crohn's disease","author":"Oguro K","year":"2022","journal-title":"Endoscopy"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1439-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.05.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04225.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.001"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000627"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02300-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15330"}],"container-title":["DEN 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